N5163

Anti-NOTCH4 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• 동의어(들): Anti-INT3, Anti-Notch homolog 4 (Drosophila)
• UNSPSC 코드: 12352203
• NACRES: NA.41
• 결합: unconjugated
• application: IHC; WB
• 클론: polyclonal
• 종 반응성: mouse, human, rat
• citations: 6
• 기술: immunohistochemistry: 1:100-1:200; western blot: 1:500-1:1,000

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen ~230 kDa; antigen ~80 kDa
• 종 반응성: mouse, human, rat
• 농도: ~1 mg/mL
• 기술: immunohistochemistry: 1:100-1:200; western blot: 1:500-1:1,000
• UniProt 수납 번호: Q99466
• 응용 분야: research pathology
• 배송 상태: dry ice
• 저장 온도: −20°C
• 유전자 정보: human ... NOTCH4(4855) ; mouse ... Notch4(18132) ; rat ... Notch4(406162)

설명

일반 설명

NOTCH homolog-4 (NOTCH4) is expressed in breast cancer.

면역원

synthetic peptide corresponding to residues 1506-1524 of human NOTCH4. This sequence is 89% identical in mouse and rat.

생화학적/생리학적 작용

NOTCH homolog-4 (NOTCH4) has an intracellular domain which detaches from the protein on activation. This domain then translocates to the nucleus and modulates transcription of genes. NOTCH4 also activates various pathways and contributes to carcinogenesis. Mutations in the gene encoding the protein may be linked to schizophrenia.

물리적 형태

solution in phosphate buffered saline, containing 0.02% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)