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Merck
모든 사진(2)

Key Documents

N2881

Sigma-Aldrich

4-Nitrophenyl phenylphosphonate

adenosine receptor agonist, 5′-Nucleotide Phosphodiesterase substrate

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About This Item

실험식(Hill 표기법):
C12H10NO5P
CAS Number:
Molecular Weight:
279.19
MDL number:
UNSPSC 코드:
12352204
PubChem Substance ID:
NACRES:
NA.32

분석

≥98% (TLC)

형태

powder

solubility

acetone: 50 mg/mL, clear, faintly yellow

저장 온도

−20°C

SMILES string

OP(=O)(Oc1ccc(cc1)N(=O)=O)c2ccccc2

InChI

1S/C12H10NO5P/c14-13(15)10-6-8-11(9-7-10)18-19(16,17)12-4-2-1-3-5-12/h1-9H,(H,16,17)

InChI key

NRGZTHQFAQCJCQ-UHFFFAOYSA-N

기질

5′-Nucleotide Phosphodiesterase substrate

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

Hydrolysis of a phosphonate ester catalyzed by an enzyme from Dictyostelium discoideum.
E F Rossomando et al.
Archives of biochemistry and biophysics, 197(1), 364-366 (1979-10-01)
H J Deussen et al.
Bioorganic & medicinal chemistry, 8(3), 507-513 (2000-03-25)
A bifunctional activity label (8) for directed molecular evolution of lipolytic enzymes has been designed and synthesized. The structure is composed of a 4-nitrophenyl activated phosphonate, that is, a suicide substrate of lipases/esterases, connected to a biotin moiety through a
M Labadie et al.
Biochimie, 61(9), 1091-1094 (1979-01-01)
A "Batch" microcalorimeter is used at 30 degrees C for the study of the hydrolysis of 4-nitro-phenylphenylphosphonate with a calf-intestinal phosphonate esterase, in a tris buffer, pH 8. The yield of enzymatic hydrolysis is estimated by spectrophotometric determination of the
O A Moe et al.
The Journal of biological chemistry, 258(11), 6941-6946 (1983-06-10)
Extensive kinetic studies of bovine intestinal 5'-nucleotide phosphodiesterase as a function of pH have confirmed and amplified the catalytic mechanism previously proposed on the basis of isolation of a covalent phosphorylated intermediate (Landt, M., and Butler, L.G. (1978) Biochemistry 17
A G Wang et al.
Ophthalmology, 106(7), 1287-1291 (1999-07-16)
To determine the cerebral metabolism of patients with cortical visual loss. Two observational case studies. Two patients who survived acute organophosphate poisoning with respiratory failure experienced severe visual loss despite relatively normal ophthalmic examination results. Magnetic resonance imaging of the

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