추천 제품
생물학적 소스
mouse
결합
unconjugated
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
RMO44, monoclonal
형태
buffered aqueous solution
종 반응성
human, mouse, rat, zebrafish
농도
~2 mg/mL
기술
immunohistochemistry: suitable
microarray: suitable
western blot: 1-2 μg/mL using extract of SHSy5y human neuroblastoma cells
동형
IgG1
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... NEFM(4741)
mouse ... Nefm(18040)
rat ... Nefm(24588)
일반 설명
Monoclonal Anti- Neurofilament 160 (mouse IgG1 isotype) is derived from the hybridoma RMO44 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified mid-sized rat neurofilament (NF-M) subunit. Neurofilaments are one of the five major groups of intermediate filaments (Ifs) and are found predominantly in cells or tissues of neuronal origin. They are composed of three major proteins of apparent molecular weights 68 kDa, 160 kDa and 200 kDa.
Neurofilament 160 (NEFM) is one among the most abundant filaments in post-mitotic neurons.
면역원
purified mid-sized rat neurofilament (NF-M) subunit.
애플리케이션
Monoclonal Anti-Neurofilament 160 antibody produced in mouse has been used in:
- enzyme-linked immunosorbent assay (ELISA)
- western blot analysis
- immunohistochemistry
- antibody labelling
생화학적/생리학적 작용
Neurofilament 160 (NEFM) associates with the dopamine receptor.
Neurofilament proteins are synthesized in the neuronal perikarya, assembled to form filaments and then slowly transported within the axons towards the synaptic terminals. These molecules undergo post-translational modifications, which results in their heterogeneity including different levels of phosphorylation. The phosphorylation of neurofilament polypeptides has been suggested to modulate their function by influencing their interaction with cytoplasmic organelles.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Neurofilaments at a glance
Journal of Cell Science, 125(14), 3257-3263 (2012)
An in vitro model for studying CNS white matter: functional properties and experimental approaches
F1000Research, 8(1) (2019)
Distribution patterns of the zebrafish neuronal intermediate filaments inaa and inab
Journal of Neuroscience Research, 97(2), 202-214 (2019)
Neuronal cytoskeletal alterations in an experimental model of depression
Neuroscience, 3-3 (2004)
The amount of neurofilaments aggregated in the cell body is controlled by their increased sensitivity to trypsin-like proteases
Journal of Cell Science, 117(6), 861-869 (2004)
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