M9441

Microsomes from Liver, Pooled

from mouse(CD-1), male

• UNSPSC 코드: 12161501
• NACRES: NA.47

속성

• 생물학적 소스: mouse (CD-1)
• Quality Level: 200
• 형태: liquid
• 포장: vial of ~10 mg
• UniProt 수납 번호: Q91VS7
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: mouse ... Mgst1(56615)

설명

일반 설명

Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).

애플리케이션

Microsomes from Liver, Pooled has been also been used to study the metabolic stability of antitumor agents and tunicamycin.

Microsomes from Liver, Pooled has been used in cell survival and mutation assays in Escherichia coli.

생화학적/생리학적 작용

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

Microsomes might act as cell organelles and are actively involved in protein synthesis. Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids. Murine liver microsomes plays a crucial role in degradation of small antimicrobial β^2,2-amino acid derivatives.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable