M0567

Microsomes from Liver, Pooled

from human male

• 동의어(들): lab equipment accessory
• UNSPSC 코드: 12352204
• NACRES: NA.54

속성

• 생물학적 소스: human male
• Quality Level: 200
• 형태: liquid
• 포장: vial of ~10 mg
• 배송 상태: dry ice
• 저장 온도: −70°C

설명

애플리케이션

Microsomes from Liver, Pooled has been used:

• in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process
• as a human liver microsomes (HLM) matrix for testing metabolic stability of talazoparib using liquid chromatography-tandem mass spectrometry (LC–MS/MS)
• to study the metabolization of enantiomeric peptide D3

Microsomes from liver have been used in a study to assess differences in enzymatic activities between normal rat livers and from liver after partial hepatectomy. They have also been used in a study to investigate the carbon monoxide-binding pigment in liver microsomes.

생화학적/생리학적 작용

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable