추천 제품
![Guanosine 5′-[γ-thio]triphosphate tetralithium salt ≥90% (contains < 10% GDP, HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/131/514/e3025b6a-cb52-4818-b20f-98efac485c1a/640/e3025b6a-cb52-4818-b20f-98efac485c1a.png)
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
whole antiserum
항체 생산 유형
primary antibodies
클론
polyclonal
포함
15 mM sodium azide
종 반응성
mammals
기술
western blot: 1:200
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... MAP2(4133) , MAPT(4137)
mouse ... Mapt(17762) , Mtap2(17756)
rat ... Map2(25595) , Mapt(29477)
일반 설명
Microtubule-associated protein 2 (MAP2) is a neuronal protein. It belongs to the MAP2/Tau family. This gene is located to human chromosome 2q34-q35. MAP2 is present in neurons. MAP2 is the major microtubule-associated protein of brain tissue. There are two major classes of heat stable MAPs; two are similarly sized with apparent molecular weights of 280kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70kDa (MAP2c).
특이성
Reacts with the two major classes of heat stable MAPs (MAP2 and τ). Does not react with MAP1 or tubulin.
면역원
heat stable MAPs prepared from bovine brain.
애플리케이션
Anti-Microtubule-Associated Proteins (MAPs) antibody produced in rabbit has been used in:
- immunofluorescent labelling
- immunohistochemistry
- immunoprecipitation
- immunofluorescence staining
- western blotting
생화학적/생리학적 작용
Microtubule-associated protein 2 (MAP2) interacts with microtubules to maintain the structure of dendrites. It plays a major role in supporting the actin cytoskeleton in spines, binding and nucleating filamentous actin (f-actin) to modulate spine morphology. Microtubules function as structural and mobility elements in mitosis, intracellular transport, flagellar movement and in the cytoskeleton.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
적합한 제품을 찾을 수 없으신가요?
당사의 제품 선택기 도구.을(를) 시도해 보세요.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Dynamic Instability of Microtubules Assembled from Microtubule-Associated Protein-Free Tubulin: Neither Variability of Growth and Shortening Rates nor ?Rescue? Requires Microtubule-Associated Proteins
Billger MA, et al.
Biochemistry, 35(42), 13656-13663 (1996)
The MAP2/Tau family of microtubule-associated proteins
Dehmelt L, et al.
Genome Biology, 6(1), 1-10 (2005)
Increased Phosphorylation of Ca/Calmodulin-dependent Protein Kinase II and Its Endogenous Substrates in the Induction of Long Term Potentiation
Fukunaga K, et al.
Test, 270(11), 6119-6124 (1995)
Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons
Coughlan CM, et al.
Neuroscience, 97(3), 591-600 (2000)
J H Holstein et al.
British journal of pharmacology, 154(5), 1055-1062 (2008-05-06)
The immunosuppressive drug rapamycin (RAPA) prevents rejection in organ transplantation by inhibiting interleukin-2-stimulated T-cell division. Rapamycin has also been suggested to possess strong anti-angiogenic activities linked to a decrease in production of vascular endothelial growth factor (VEGF). Angiogenesis and VEGF
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.