추천 제품
생물학적 소스
guinea pig brain
Quality Level
분석
≥80% (SDS-PAGE)
형태
lyophilized powder
UniProt 수납 번호
응용 분야
cell analysis
저장 온도
−20°C
유전자 정보
guinea pig ... MBP(100731253)
일반 설명
Myelin Basic Protein (MBP) expressed in guinea pig brain contains 167 amino acids and has a molecular weight of 18,256Da.
Myelin basic protein (MBP), an important constituent of the myelin sheath of CNS (central nervous system). It is an autoimmunogen. MBP is mapped to human chromosome 18q.
애플리케이션
Myelin Basic Protein from guinea pig brain has been used as a component in emulsion to induce experimental autoimmune encephalitis (EAE).
생화학적/생리학적 작용
Mutation of the myelin basic protein gene induces dysmyelination; used to induce experimental allergic encephalomyelitis.
Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme.
품질
May contain traces of urea-glycine buffer salts.
원리
Used as a kinase substrate.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Karine Thibault et al.
European journal of pain (London, England), 15(3), 231-231 (2010-09-11)
Multiple sclerosis is a chronic inflammatory demyelinating disease, associated, in 50-80% of patients, with persistent pain. While the type of pain that affects these patients is being more documented, the mechanisms underlying this pathology are still poorly understood and animal
Sequence of guinea pig myelin basic protein.
Deibler GE
Journal of Neurochemistry, 43(1), 100-105 (1984)
Metallic gold slows disease progression, reduces cell death and induces astrogliosis while simultaneously increasing stem cell responses in an EAE rat model of multiple sclerosis
Pedersen DS, et al.
Histochemistry and Cell Biology, 138(5), 787-802 (2012)
Glucagon-Like Peptide-1 Analog, Liraglutide, Delays Onset of Experimental Autoimmune Encephalitis in Lewis Rats
Della VB, et al.
Frontiers in Pharmacology, 7, 787-802 (2016)
Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain.
Campagnoni AT, et al.
Test, 268(7), 4930-4938 (1993)
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.