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Merck
모든 사진(3)

주요 문서

L6895

Sigma-Aldrich

Lipid A, monophosphoryl from Salmonella enterica serotype minnesota Re 595 (Re mutant)

lyophilized powder, TLR ligand tested

동의어(들):

Monophosphoryl Lipid A from Salmonella

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About This Item

MDL number:
UNSPSC 코드:
12352211
NACRES:
NA.25

생물학적 소스

Salmonella enterica (serotype minnesota Re 595 Re mutant)

Quality Level

양식

lyophilized powder

불순물

<0.2% Ketodeoxyoctonate (KDO)

배송 상태

ambient

저장 온도

2-8°C

애플리케이션

Lipid A molecules compose the lipid membrane anchoring core components of endotoxins produced by Gram-negative bacteria. Lipid A molecules induce immune responses. Structually, lipid A molecules are composed of two glucosamine units with varied, species dependent, fatty acyl chain numbers and identity and degree of phosphorylation.
Lipid A, monophosphoryl from Salmonella enterica serotype minnesota Re 595 may be used in comparative assessment of the antigenicity of specific structures within different LPA molecules and analogues.

생화학적/생리학적 작용

Lipid A has immunostimulatory adjuvant activity including macrophage, T-cell, and B-cell activation. Research has shown Lipid A has greater Th1 than Th2 stimulation.
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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