L6295
Lomerizine dihydrochloride
≥98% (HPLC), powder
동의어(들):
1-[Bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C27H30F2N2O3·2HCl
CAS Number:
Molecular Weight:
541.46
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.25
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to tan
solubility
DMSO: ≥30 mg/mL
저장 온도
2-8°C
SMILES string
Cl.Cl.COc1ccc(CN2CCN(CC2)C(c3ccc(F)cc3)c4ccc(F)cc4)c(OC)c1OC
InChI
1S/C27H30F2N2O3.2ClH/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20;;/h4-13,25H,14-18H2,1-3H3;2*1H
InChI key
LOGVKVSFYBBUAJ-UHFFFAOYSA-N
생화학적/생리학적 작용
Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator.
Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator. It is one of the most selective calcium channel blockers for the CNS and cerebral arteries. It has been reported to inhibit both T-type and L-type Ca2+ currents in rat hippocampal CA1 pyramidal neurons, to prevent glutamate-induced neurotoxicity in rat hippocampal primary cell cultures, and to exhibit protective effects in animal models of migraine, ischemia and hypoxia. In Japan, lomerizine has been used as the first-line prophylactic drug for migraines.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Do the effects of long-term lomerizine administration differ with age?
Noboru Imai et al.
Internal medicine (Tokyo, Japan), 46(10), 683-684 (2007-05-29)
Shinichi Iwasaki et al.
Acta oto-laryngologica. Supplementum, (559)(559), 45-49 (2008-04-12)
Lomerizine, a calcium channel blocker, may be effective as a treatment for migraine-associated vertigo (MAV). Objective. To determine the clinical characteristics of patients with MAV in Japan and the effectiveness of lomerizine. This was a retrospective chart review carried out
Luan T Tran et al.
Journal of neurochemistry, 130(3), 455-466 (2014-04-11)
Excitotoxicity and disruption of Ca(2+) homeostasis have been implicated in amyotrophic lateral sclerosis (ALS) and limiting Ca(2+) entry is protective in models of ALS caused by mutation of SOD1. Lomerizine, an antagonist of L- and T-type voltage-gated calcium channels and
Yukiko Tada et al.
Internal medicine (Tokyo, Japan), 48(24), 2141-2144 (2009-12-17)
Short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) is a rare primary headache syndrome. The diagnostic criteria include attacks of unilateral orbital, supraorbital or temporal stabbing pain accompanied by one of the following: conjunctival injection and/or tearing, nasal
Toshiki Mizuno et al.
Clinical neuropharmacology, 32(2), 113-116 (2009-06-11)
A 64-year-old woman was admitted to our hospital for recurrent stroke and cognitive impairment and was diagnosed with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Iodine-123 iodoamphetamine single photon emission computed tomography showed hypoperfusion in the whole
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