추천 제품
재조합
expressed in E. coli
Quality Level
설명
200 amino acid residue methionyl form of mature, recombinant human prolactin (amino acid residues 29-227).
제품 라인
BioReagent
분석
>97% (SDS-PAGE)
형태
lyophilized powder
효능
0.030-0.300 ng/mL EC50
분자량
predicted mol wt ~24 kDa
기술
cell culture | mammalian: suitable
불순물
endotoxin, tested
solubility
water: 0.5000 mL, clear, colorless
UniProt 수납 번호
배송 상태
ambient
저장 온도
−20°C
유전자 정보
human ... PRL(5617)
애플리케이션
Use in cell culture applications to study prolactin regulation of cell signaling and gene expression.
생화학적/생리학적 작용
Prolactin is a neuroendocrine hormone. The prolactin receptor is a transmembrane glycoprotein that belongs to the cytokine hematopoietic receptor family. A large number of cells and organs express the receptor, including B cells, T cells, macrophages, monocytes, and neutrophils. Prolactin signal transduction involves the JAK/STAT families and the src kinase family. Induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.
기타 정보
Contains an N-terminal methionine not present in the natural product.
물리적 형태
Lyophilized from a solution in 10 mM phosphate and 50 mM sodium chloride, pH 8.0.
재구성
It is recommended that sterile 4 mM HCl containing 1 mg/mL bovine serum albumin be added to the vial to prepare a stock solution of no less than 100 μg/mL.
분석 메모
The biological activity is assayed by proliferation of the rat lymphoma cell line, Nb2-11.
신호어
Danger
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Regulatory action of prolactin on the in vitro growth of CD34+ve human hemopoietic progenitor cells.
G Bellone et al.
Journal of cellular physiology, 163(2), 221-231 (1995-05-01)
The pituitary hormone prolactin (Prl) is known to act as a local regulator of immune cell function, and Prl-binding receptors (Prl-R) have been described to share distinctive features with the members of the newly described cytokine/hemopoietin receptor superfamily. Here we
Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects.
N Ben-Jonathan et al.
Endocrine reviews, 17(6), 639-669 (1996-12-01)
Khalid Bajou et al.
Nature medicine, 20(7), 741-747 (2014-06-16)
The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor
Etienne Delgrange et al.
European journal of endocrinology, 170(1), 31-38 (2013-10-04)
To characterise distinctive clinical features of giant prolactinomas in women. A multicentre, retrospective case series and literature review. We collected data from 15 female patients with a pituitary tumour larger than 4 cm and prolactin levels above 1000 μg/l and
Akie Nakamura et al.
The Journal of clinical endocrinology and metabolism, 98(10), E1682-E1691 (2013-08-24)
Congenital central hypothyroidism (C-CH) is a rare disease. We investigated the molecular basis of unexplained C-CH in 4 Japanese boys. C-CH was diagnosed by low free T4 and/or T3 and low basal TSH concentrations. We used whole-exome sequencing of one
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