추천 제품
생물학적 소스
human plasma
Quality Level
분석
≥95% (SDS-PAGE)
양식
lyophilized powder
분자량
64000 Da
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
유전자 정보
human ... KNG1 (includes EG:3827)
애플리케이션
Kininogen, low molecular weight from human plasma has been used to study rMASP-1 (recombinant mannose-binding lectin-associated serine protease 1)-mediated cleavage of LK (low molecular weight kininogen). It has been used as a standard for protein identification in milk-proteomics study.
생화학적/생리학적 작용
Extracellular cysteine proteinase inhibitor.
LMW kininogen is a major extracellular cysteine proteinase inhibitor. Tissue kallikrein releases bradykinin, a potent bronchoconstrictor and vasoactive agent, from both HMW and LMY kininogen.
물리적 형태
Lyophilized from a solution in sodium acetate and sodium chloride.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Xavier Charest-Morin et al.
Pharmacology research & perspectives, 3(2), e00119-e00119 (2015-06-04)
Tissue kallikrein (KLK-1), a serine protease, initiates the release of bradykinin (BK)-related peptides from low-molecular weight kininogen. KLK-1 and the BK B2 receptor (B2R) mediate beneficial effects on the progression of type 2 diabetes and renal disease, but the precise
Delphine Vincent et al.
Frontiers in genetics, 6, 360-360 (2016-01-23)
Milk is a complex fluid whose proteome displays a diverse set of proteins of high abundance such as caseins and medium to low abundance whey proteins such as ß-lactoglobulin, lactoferrin, immunoglobulins, glycoproteins, peptide hormones, and enzymes. A sample preparation method
József Dobó et al.
PloS one, 6(5), e20036-e20036 (2011-06-01)
Bradykinin (BK), generated from high-molecular-weight kininogen (HK) is the major mediator of swelling attacks in hereditary angioedema (HAE), a disease associated with C1-inhibitor deficiency. Plasma kallikrein, activated by factor XIIa, is responsible for most of HK cleavage. However other proteases
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