형태
buffered aqueous solution
Quality Level
특이 활성도
≥5 units/mg protein
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
유전자 정보
human ... KLK1(3816)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Kallikrein-related peptidases belong to the family of 15 highly conserved trypsin- or chymotrypsin-like serine proteases. Plasma kallikrein (PK) is a serine protease derived from plasma prekallikrein, a zymogen found at higher levels in blood circulation. The KLKB1 gene is located on the human chromosome at 4q35.2.
애플리케이션
Kallikrein from human plasma has been used:
- to culture human hepatocellular carcinoma cell line
- to study its effects on the cleavage of Neisserial heparin binding antigen (NHBA) from Neisseria meningitidis
- in peptidase inhibition assay
생화학적/생리학적 작용
Plasma kallikrein (PK) is involved in the synthesis of bradykinin, maintaining the blood metabolite levels and hypertension. It also participates in the activation of coagulation factor XII, which promotes inflammation and the intrinsic coagulation pathway. PK controls proteolytic cascades in the cardiovascular system like the kallikrein-kinin system, renin-angiotensin system, fibrinolytic system, and the alternative complement pathway. It is involved in the cleavage of glucagon-like peptide-1 (GLP-1) and neuropeptide Y (NPY) which suggests that plasma kallikrein may affect metabolism and diabetes.
단위 정의
One unit will hydrolyze 1.0 μmole of Nα-benzoyl-L-arginine ethyl ester (BAEE) to Nα-benzoyl-L-arginine and ethanol per min at pH 8.7 at 25°C.
물리적 형태
Solution in 20 mM Tris-HCl, pH 7.8 with 100 mM NaCl.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Xueqing Xu et al.
Nucleic acids research, 37(22), 7381-7393 (2009-10-13)
A subtelomeric region, 4q35.2, is implicated in facioscapulohumeral muscular dystrophy (FSHD), a dominant disease thought to involve local pathogenic changes in chromatin. FSHD patients have too few copies of a tandem 3.3-kb repeat (D4Z4) at 4q35.2. No phenotype is associated
Elisa Pantano et al.
PloS one, 14(8), e0203234-e0203234 (2019-08-02)
Neisserial Heparin Binding Antigen (NHBA) is a surface-exposed lipoprotein of Neisseria meningitidis and a component of the Bexsero vaccine. NHBA is characterized by the presence of a highly conserved Arg-rich region involved in binding to heparin and heparan sulphate proteoglycans
H Austin et al.
Journal of thrombosis and haemostasis : JTH, 9(3), 489-495 (2011-01-15)
We evaluated 10 single-nucleotide polymorphisms (SNPs) identified in three European case-control studies as risk factors for venous thrombosis. We sought to replicate the positive findings from this report among Whites and to evaluate the association of these SNPs with venous
L E Stolz et al.
Drugs of today (Barcelona, Spain : 1998), 46(8), 547-555 (2010-09-11)
Hereditary angioedema (HAE) is a debilitating, potentially fatal disease characterized by variable and unpredictable acute attacks of swelling affecting the subcutaneous tissue and mucosa. It is an autosomal dominant disorder resulting from a genetic deficiency of functional C1-esterase inhibitor. Available
A new case of homozygous C1-inhibitor deficiency suggests a role for Arg378 in the control of kinin pathway activation.
Alberto López-Lera et al.
The Journal of allergy and clinical immunology, 126(6), 1307-1310 (2010-09-25)
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