추천 제품
product name
Keratinocyte Growth Factor human, KGF, recombinant, expressed in E. coli, powder, suitable for cell culture
생물학적 소스
human
Quality Level
재조합
expressed in E. coli
분석
≥95% (SDS-PAGE and HPLC)
형태
powder
효능
0.1-15 ng/mL ED50/EC50
품질
endotoxin tested
분자량
18.9 kDa
포장
pkg of 10 and 50 μg
기술
cell culture | mammalian: suitable
불순물
1 EU/μg
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... FGF7(2252)
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일반 설명
Keratinocyte Growth Factor(KGF) is a 18.9 kDa growth factor, spanning 163 amino acids, belongs to the fibroblast growth factor family. It includes a secretory signal sequence and shares 39% identity with FGF-Basic. It is expressed in a number of stromal fibroblast cell lines, mesenchymal cells but absent from normal glial cells and epithelial cell lines.
애플리케이션
Keratinocyte Growth Factor human has been used:
- as a component of epithelial growth medium
- as a positive control for antigen to determine the activity of the antibody
- to analyze the influence of KGF associated with thermo-sterilized carboxymethyl chitosan (NOCCts) in the reduction of pericardial adhesions
생화학적/생리학적 작용
Keratinocyte Growth Factor(KGF) stimulates proliferation and differentiation of keratinocytes and other cells in the epithelium. It induces chemotaxis of microvascular endothelial cells and neovascularization of rat cornea. It stimulates the hyaluronic acid synthesis in proliferating and migrating basal cells. KGF contributes to the survival of cells under stress conditions. KGF is highly expressed in injured and inflamed epithelial cells, thereby, promotes wound healing.
물리적 형태
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.
분석 메모
Determined by a cell proliferation assay using 4MBr-5 cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Characteristics of MIC-1 antlerogenic stem cells and their effect on hair growth in rabbits.
Cegielski M, et al.
In Vivo, 27(1), 97-106 (2013)
P Gillis et al.
Journal of cell science, 112 ( Pt 12), 2049-2057 (1999-05-26)
Keratinocyte growth factor (KGF), also called fibroblast growth factor-7, is widely known as a paracrine growth and differentiation factor that is produced by mesenchymal cells and has been thought to act specifically on epithelial cells. Here it is shown to
Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration
Alpdogan O, et al.
Blood, 107(6), 2453-2460 (2006)
Stimulation of in vivo angiogenesis by in situ crosslinked, dual growth factor-loaded, glycosaminoglycan hydrogels
Elia R, et al.
Biomaterials, 31(17), 4630-4638 (2010)
Synergism between keratinocyte growth factor and carboxymethyl chitosan reduces pericardial adhesions
Lopes JB, et al.
The Annals of Thoracic Surgery, 90(2), 566-572 (2010)
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