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I9646

Sigma-Aldrich

IL-6 mouse

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

동의어(들):

mIL-6, IL-6

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모든 사진(2)

About This Item

MDL number:
MFCD01656039
UNSPSC 코드:
12352202
NACRES:
NA.77

product name

Interleukin-6 from mouse, IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, carrier free

생물학적 소스

mouse

Quality Level

200

재조합

expressed in E. coli

분석

≥97% (SDS-PAGE)

형태

lyophilized powder

효능

0.02-0.2 ng/mL EC50

품질

endotoxin tested

분자량

~21.7 kDa

포장

pkg of 5 and 25 μg

기술

cell culture | mammalian: suitable

불순물

≤1.0EU/mg

색상

white

UniProt 수납 번호

P08505

저장 온도

−20°C

유전자 정보

mouse ... Il6(16193)

생화학적/생리학적 작용

Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.

물리적 형태

Lyophilized from a sterile filtered solution with no additives.

분석 메모

The biological activity of recombinant mouse IL-6 was measured in a cell proliferation assay using T1165.85.2.1 cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Jee Eun Choi et al.
STAR protocols, 3(2), 101389-101389 (2022-05-24)
Metabolic reprogramming is associated with myeloid-derived suppressor cell (MDSC) immunosuppressive function. Here, we outline the process for acquiring MDSCs from human and murine sources for subsequent analysis of fatty acid oxidation, oxidative phosphorylation, and glycolysis using the Seahorse XFe 96
Marrah E Lachowicz-Scroggins et al.
American journal of respiratory cell and molecular biology, 43(6), 652-661 (2010-01-19)
Infection of airway epithelium by rhinovirus is the most common cause of asthma exacerbations. Even in mild asthma, airway epithelium exhibits mucous metaplasia, which increases with increasing severity of the disease. We previously showed that squamous cultures of human airway
Gregory J Tesz et al.
The Journal of biological chemistry, 282(27), 19302-19312 (2007-05-15)
Tumor necrosis factor alpha (TNFalpha) is a cytokine secreted by macrophages and adipocytes that contributes to the low grade inflammation and insulin resistance observed in obesity. TNFalpha signaling decreases peroxisome proliferator-activated receptor gamma and glucose transporter isoform 4 (GLUT4) expression
R P Nordan et al.
Journal of immunology (Baltimore, Md. : 1950), 139(3), 813-817 (1987-08-01)
Plasmacytoma growth factor (PCT-GF), a putative macrophage-derived lymphokine essential for the in vitro viability and proliferation of early generation plasmacytomas, was purified from conditioned medium of the murine macrophage cell line P388D1. The purification of PCT-GF was accomplished by a
Suzanne Speck et al.
PloS one, 9(7), e102390-e102390 (2014-07-30)
While the role of Transforming Growth Factor β (TGF-β) as an intrinsic pathway has been well established in driving de novo differentiation of Th17 cells, no study has directly assessed the capacity of TGF-β signaling initiated within dendritic cells (DCs)
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