I7016

H-7 dihydrochloride

≥98% (HPLC)

• 동의어(들): 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride, Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride
• 실험식(Hill 표기법): C₁₄H₁₇N₃O₂S · 2HCl
• CAS Number: 108930-17-2
• Molecular Weight: 364.29
• Beilstein: 5840763
• MDL number: MFCD00036961
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278496
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: powder
• solubility: H₂O: 20 mg/mL
• 저장 온도: 2-8°C
• SMILES string: Cl.Cl.CC1CNCCN1S(=O)(=O)c2cccc3cnccc23
• InChI: 1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H
• InChI key: OARGPFMFRLLKPF-UHFFFAOYSA-N
• 유전자 정보: human ... PRKCA(5578) , PRKCB(5579) , PRKCD(5580) , PRKCE(5581) , PRKCG(5582) , PRKCH(5583) , PRKCI(5584)

설명

일반 설명

H-7 dihydrochloride blocks human immunodeficiency virus (HIV-1) replication in MOLT-4 (clone No. 8) cell line. It increases the secretion of interleukin 1β (IL-1β).

애플리케이션

H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

생화학적/생리학적 작용

Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C.

주의사항

Light sensitive

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)