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Merck
모든 사진(1)

주요 문서

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I0779

Sigma-Aldrich

Interleukin-2 Soluble Receptor α human

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

동의어(들):

CD25, IL-2 sRα, Tac antigen

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모든 사진(1)

About This Item

MDL number:
MFCD01323736
UNSPSC 코드:
51111800
NACRES:
NA.32

생물학적 소스

human

Quality Level

200

재조합

expressed in NSO cells

분석

>97% (SDS-PAGE)

양식

lyophilized powder

효능

0.5-1.0 mg per mL ED50

분자량

36 kDa by SDS-PAGE

포장

pkg of 5 μg

불순물

endotoxin, tested

UniProt 수납 번호

P01589

저장 온도

−20°C

유전자 정보

human ... IL2RA(3559)

생화학적/생리학적 작용

Interleukin-2 (IL-2), a cytokine, enhances Th (T helper) cell differentiation and effector responses. In addition, it helps in immune tolerance. IL-2 binds to the high affinity receptor, formed of IL2RA (interleukin 2 receptor subunit α), IL2RB (interleukin 2 receptor subunit β) and γ-chain. Polymorphism in IL2RA is associated with multiple sclerosis. Null mutation in IL2RA results in immune dysregulation.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.

분석 메모

The bioactivity is measured by its ability to inhibit the IL-2-dependent proliferation of a human megakaryocytic leukemic cell line, M07e.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
SLCD6594
SLCD1647
SLBX1183
SLBH3318
061M1265

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

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문서 라이브러리 방문

Kevin Goudy et al.
Clinical immunology (Orlando, Fla.), 146(3), 248-261 (2013-02-19)
Cell-surface CD25 expression is critical for maintaining immune function and homeostasis. As in few reported cases, CD25 deficiency manifests with severe autoimmune enteritis and viral infections. To dissect the underlying immunological mechanisms driving these symptoms, we analyzed the regulatory and
G C Avanzi et al.
British journal of haematology, 69(3), 359-366 (1988-07-01)
A new human leukaemic cell line (M-O7) with the phenotypic characteristics of CFU-mega is described. Its cells are positive for T200 leucocyte common antigen (LCA) and negative with MAbs recognizing T and B cells and mature myelomonocytic antigens. In contrast
Felix J Hartmann et al.
Nature communications, 5, 5056-5056 (2014-10-04)
Genome-wide association studies implicate dysregulation of immune mechanisms in the pathogenesis of multiple sclerosis (MS). Particularly, polymorphisms in genes involved in T helper (TH) cell differentiation are associated with risk of developing MS. However, the underlying mechanism by which these

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