추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
제품 라인
Prestige Antibodies® Powered by Atlas Antibodies
형태
buffered aqueous glycerol solution
종 반응성
human
기술
immunohistochemistry: 1:20- 1:50
면역원 서열
RHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKT
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... HSD3B1(3283)
일반 설명
3 β-hydroxysteroid dehydrogenase/delta 5->4-isomerase type 1 (HSD3B1) is a key enzyme essential for the formation of steroid sex hormones. It is majorly expressed in mammary glands, prostate, placenta and sebaceous glands of skin. HSD3B1 gene is mapped to human chromosome 1p12 and has four exons.
면역원
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
애플리케이션
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
생화학적/생리학적 작용
3 β-hydroxysteroid dehydrogenase/delta 5->4-isomerase type 1 (HSD3B1) catalyses the conversion of steroid dehydroepiandrosterone sulfate to estrogen precursors hormones. It regulates levels of dihydrotestosterone (DHT). HSD3B1 is highly expressed in breast cancer and HSD3B1 gene knockdown results in tumor growth inhibition. A single nucleotide polymorphism in the HSD3B1 gene enhances enzyme activity and improves dihydrotestosterone (DHT) production in castration-resistant prostate cancer (CRPC). Expression of HSD3B1 is downregulated in ovarian cancer. Polymorphism in HSD3B1 is implicated in individuals with hypertension.
특징 및 장점
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
결합
Corresponding Antigen APREST82530
물리적 형태
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
법적 정보
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Hormones and the Endocrine System, 191-236 (2016)
Metabolism of dihydrotestosterone in human liver: importance of 3alpha-and 3beta hydroxysteroid dehydrogenase
Pirog EC and Collins DC
The Journal of Clinical Endocrinology and Metabolism, 84(9), 3217-3221 (1999)
Polymorphism in exon 4 of the human 3beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure
Rosmond R, et al.
Biochemical and Biophysical Research Communications, 293(1), 629-632 (2002)
Identification of underexpressed genes in early-and late-stage primary ovarian tumors by suppression subtraction hybridization
Shridhar V, et al.
Cancer Research, 62(1), 262-270 (2002)
Variant allele of HSD3B1 increases progression to castration-resistant prostate cancer
Wu G, et al.
Prostate, 75(7), 777-782 (2015)
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