추천 제품
생물학적 소스
mouse
항체 형태
purified from hybridoma cell culture
항체 생산 유형
primary antibodies
클론
SD-G6, monoclonal
양식
buffered aqueous solution
종 반응성
human, rat, canine
포장
antibody small pack of 25 μL
기술
indirect ELISA: 0.3-0.6 μg/mL using 5μg/ml Superoxide Dismutase from human erythrocytes for coating
동형
IgG1
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... SOD1(6647)
일반 설명
Superoxide Dismutase (SOD) is a family of metalloenzymes widely distributed in both plants and animals. Superoxide dismutases appear to protect cells against reactive free radicals by scavenging the superoxide radicals produced by ionization radiation or through other mechanisms. SOD enzyme catalyzes the conversion of single electron reduced species of molecular oxygen to hydrogen peroxide and oxygen. There are several classes of SOD that differ in their metal binding ability, distribution in different cell compartments, and sensitivity to various reagents. Among these, Cu, Zn superoxide dismutase (SOD1) is widely distributed and comprises 90% of the total SOD. This ubiquitous enzyme, which requires Cu and Zn for its activity, has great physiological significance and therapeutic potential.
면역원
recombinant human copper-zinc superoxide dismutase (Cu-Zn-SOD).
애플리케이션
Monoclonal Anti-Superoxide Dismutase (SOD) recognizes natural (human erythrocyte SOD), recombinant SOD (human Cu-Zn-SOD and human placental SOD) and the enzymatically inactive form of these enzymes. Reactivity has been observed with SOD from human, rat and dog origin, no reactivity was observed with SOD from bovine, bacillus stearothermophilus or E. coli (Fe or Mn) origin. The antibody is recommended to use in various immunological techniques, including ELISA, Immunohistochemistry and immunofluorescence.
물리적 형태
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
기타 정보
This product is for R&D use only, not for drug, household, or other uses.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
H D Durham et al.
Journal of neuropathology and experimental neurology, 56(5), 523-530 (1997-05-01)
Mutations in the Cu/Zn-superoxide dismutase (SOD-1) gene underlie some familial cases of amyotrophic lateral sclerosis (FALS), a neurodegenerative disorder characterized by loss of cortical, brainstem, and spinal motor neurons. To investigate the mechanisms responsible for the toxicity of mutant enzyme
Rana Noor et al.
Medical science monitor : international medical journal of experimental and clinical research, 8(9), RA210-RA215 (2002-09-10)
Reactive oxygen species, such as superoxide radicals, are thought to underlie the pathogenesis of various diseases. Almost 3 to 10% of the oxygen utilized by tissues is converted to its reactive intermediates, which impair the functioning of cells and tissues.
Delira Robbins et al.
Antioxidants & redox signaling, 20(10), 1628-1645 (2013-05-28)
Cancer is the second leading cause of death in the United States. Considering the quality of life and treatment cost, the best way to fight against cancer is to prevent or suppress cancer development. Cancer is preventable as indicated by
J Muchová et al.
Physiological research, 63(5), 535-542 (2014-06-09)
Oxidative stress is a phenomenon associated with imbalance between production of free radicals and reactive metabolites (e.g. superoxide and hydrogen peroxide) and the antioxidant defences. Oxidative stress in individuals with Down syndrome (DS) has been associated with trisomy of the
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