추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in HEK 293 cells
분석
≥95% (SDS-PAGE)
형태
lyophilized powder
효능
≤0.1-1.5 ng/mL EC50
품질
endotoxin tested
분자량
dimer 30 kDa (glycosylated)
포장
pkg of 5X10 μg
pkg of 10 μg
기술
cell culture | mammalian: suitable
불순물
≤1 EU/μg
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... OSM(5008)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
생화학적/생리학적 작용
Oncostatin M (OSM), LIF, G-CSF, IL-6, and CNTF are structurally related members of the same cytokine family sharing similarities in their primary amino acid sequences, predicted secondary structure, and receptor components. OSM is a growth-regulating cytokine, affecting a number of tumor and normal cells. This material was first identified by its ability to inhibit the growth of A375 melanoma cells and other human tumor cells, but not inhibit the growth of normal human fibroblasts. It acts synergistically with TGF β1 to inhibit the proliferation of tumor cells like A375 melanoma cells. It induces an increase in LDL receptor expression and LDL uptake by hepatoma cells. OSM activates synovial fibroblast-like cells to produce urokinase type plasminogen activator. OSM is secreted by macrophages and activated T lymphocytes.
물리적 형태
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
분석 메모
The activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (humanerythroleukemic indicator cell line)
법적 정보
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Yuxin Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(42), 16975-16980 (2013-10-02)
The activation of STAT3 by tyrosine phosphorylation, essential for normal development and for a normal inflammatory response to invading pathogens, is kept in check by negative regulators. Abnormal constitutive activation of STAT3, which contributes to the pathology of cancer and
N Kanda et al.
Allergy, 67(6), 804-812 (2012-04-11)
Skin lesions with atopic dermatitis (AD) are associated with dysregulated expression of LL-37 and enhanced expression of IL-22, thymic stromal lymphopoietin (TSLP), IL-25, IL-31, and oncostatin M. Vitamin D3 enhances LL-37 production in keratinocytes. This study aimed to examine the
Andrea Rinaldi et al.
British journal of haematology, 163(2), 194-204 (2013-08-22)
In a fraction of patients, chronic lymphocytic leukaemia (CLL) can transform to Richter syndrome (RS), usually a diffuse large B-cell lymphoma (DLBCL). We studied genome-wide promoter DNA methylation in RS and clonally related CLL-phases of transformed patients, alongside de novo
Vicky Nicolaidou et al.
PloS one, 7(7), e39871-e39871 (2012-07-18)
A major therapeutic challenge is how to replace bone once it is lost. Bone loss is a characteristic of chronic inflammatory and degenerative diseases such as rheumatoid arthritis and osteoporosis. Cells and cytokines of the immune system are known to
Yu-Fan Chen et al.
Hepatology (Baltimore, Md.), 55(4), 1193-1203 (2011-11-19)
Liver transplantation is the only definitive treatment for end-stage cirrhosis and fulminant liver failure, but the lack of available donor livers is a major obstacle to liver transplantation. Recently, induced pluripotent stem cells (iPSCs) derived from the reprogramming of somatic
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