추천 제품
생물학적 소스
chicken
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
종 반응성
rat, mouse, human
제조업체/상표
Genway 15-288-20031F
기술
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... LEP(3952)
애플리케이션
Anti-Leptin antibody produced in chicken has been used for the immunohistochemistry study of mouse embryo and ovum. It is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.
생화학적/생리학적 작용
LEP (leptin) encoded protein plays a key role in the regulation of body weight. It is secreted by white adipocytes. It has a key role in regulating the signaling pathway that can inhibit food intake and/or control energy expenditure to maintain constancy of the adipose mass. It is also involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Defects in this gene can cause a rare disease characterized by low levels of serum leptin, severe hyperphagia and severe obesity, and morbid obesity with hypogonadism.
물리적 형태
Solution in phosphate buffered saline containing 0.02% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
가장 최신 버전 중 하나를 선택하세요:
F F Chehab
Trends in pharmacological sciences, 21(8), 309-314 (2000-08-05)
Leptin, an adipocyte-derived hormone, informs neuroendocrine pathways about the status of energy stores in adipose tissue. The integration of this peripheral signal in hypothalamic networks results in activation of peripheral metabolic pathways that control energy build-up and expenditure. Firing of
Laura C Schulz et al.
Reproduction (Cambridge, England), 141(6), 767-777 (2011-03-30)
The hormone leptin, which is primarily produced by adipose tissue, is a critical permissive factor for multiple reproductive events in the mouse, including implantation. In the CD1 strain, maternally derived leptin from the oocyte becomes differentially distributed among the blastomeres
N Patel et al.
The Journal of biological chemistry, 274(32), 22729-22738 (1999-07-31)
We report the expression cloning of a novel leptin-binding protein of the immunoglobulin superfamily (OB-BP1) and a cross-hybridizing clone (OB-BP2) that is identical to a recently described sialic acid-binding I-type lectin called Siglec-5. Comparisons to other known Siglec family members
A leptin missense mutation associated with hypogonadism and morbid obesity.
A Strobel et al.
Nature genetics, 18(3), 213-215 (1998-03-21)
G M Lord et al.
Nature, 394(6696), 897-901 (1998-09-11)
Nutritional deprivation suppresses immune function. The cloning of the obese gene and identification of its protein product leptin has provided fundamental insight into the hypothalamic regulation of body weight. Circulating levels of this adipocyte-derived hormone are proportional to fat mass
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