추천 제품
포장
pack of 2500 U
제조업체/상표
Cytiva E70073Z
배송 상태
dry ice
저장 온도
−20°C
일반 설명
Exonuclease I.
The EXO1 (exonuclease I) gene is mapped to human chromosome 1q43 and codes for a 5′→3′ exonuclease of 846 amino acids. It belongs to the 5′-nuclease superfamily.
애플리케이션
Acts specifically on single-stranded DNA degrading it processively in the 3′- to 5′-direction, producing 5′-mononucleotides.
생화학적/생리학적 작용
Exonuclease I (EXO1) maintains genomic stability by participating in DNA mismatch repair system, DNA recombination, DNA replication and DNA double-stranded break repair in eukaryotes. It also modulates meiosis, immunoglobulin maturation, and micro-mediated end-joining. It functions on DNA with blunt, nicked, gapped and 3′-overhangs. It also possesses endonuclease action and removes 5′-single-stranded flaps that protrudes from a double stranded DNA. Mutation in EXO1 gene results in increased susceptibility to develop cancer.
특징 및 장점
- Eliminating residual single-stranded DNA containing a 3′-terminus.
- Measuring endonucleolytic cleavage of covalently closed circular (ccc) ssDNA.
- Measuring DNA helicase activity.
저장 및 안정성
Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
분석 메모
To view the Certificate of Analysis for this product, please visit www.cytiva.com.
Storage Class Code
12 - Non Combustible Liquids
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Human Exonuclease 1 Threads 5?-Flap Substrates through Its Helical Arch.
Shaw S J, et al.
Biochemistry, 56(29), 3704-3707 (2017)
Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma.
Tan S, et al.
Oncotarget, 7(52), 87180-87180 (2016)
Exonuclease 1 and its versatile roles in DNA repair.
Keijzers G, et al.
Critical Reviews in Biochemistry and Molecular Biology, 51(6), 440-451 (2016)
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