추천 제품
ligand
recombinant protein A (E. coli)
포장
pack of 25 mL
제조업체/상표
Cytiva 17-5269-07
저장 조건
(20% Ehtanol)
Matrix
highly cross-linked agarose
평균 부품 크기
75 (d₅₀v is the median particle size of the cumulative volume distribution)
cleaning in place
2-12
작동 범위
3-10
용량
≥30 mg binding capacity (humanlgG/ml at 2.4 min residence time)
적합성
suitable for bioprocess medium
저장 온도
2-8°C
일반 설명
Determined at 10% breakthrough by frontal analysis at a mobile phase velocity of 500 cm/h in a column with a bed height of 20 cm.
MabSelect™ Xtra, with extra high dynamic binding capacity, is a member of the MabSelect™ family. Developed to meet the demands of increasing levels of expression in monoclonal antibody feedstocks.
MabSelect™ Xtra has the same recombinant Protein A ligand as MabSelect™ but is based on a high-flow agarose base matrix with increased porosity and a slightly decreased particle size compared to MabSelect. This results in higher capacity—MabSelect™ Xtra has about 30% higher dynamic binding capacity for IgG than currently available Protein A chromatography media.
In addition, MabSelect™ Xtra has a higher capacitiy for many Fc-fusion proteins.
The medium provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches.
MabSelect™ Xtra is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development.
As member of the BioProcess media range, MabSelect™ Xtra meets industrial demands with security of supply and comprehensive technical and regulatory support.
MabSelect™ Xtra has the same recombinant Protein A ligand as MabSelect™ but is based on a high-flow agarose base matrix with increased porosity and a slightly decreased particle size compared to MabSelect. This results in higher capacity—MabSelect™ Xtra has about 30% higher dynamic binding capacity for IgG than currently available Protein A chromatography media.
In addition, MabSelect™ Xtra has a higher capacitiy for many Fc-fusion proteins.
The medium provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches.
MabSelect™ Xtra is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development.
As member of the BioProcess media range, MabSelect™ Xtra meets industrial demands with security of supply and comprehensive technical and regulatory support.
pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.
pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.
특징 및 장점
- Higher dynamic binding capacity than currently available Protein A chromatography media.
- Improved process economics through reduced raw materials costs and/or reduced number of cycles
- High purity capture due to high ligand selectivity and matrix hydrophilicity
- Slightly lower pressure/flow properties compared to MabSelect™ SuRe™ and MabSelect
저장 및 안정성
Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
분석 메모
To view the Certificate of Analysis for this product, please visit www.cytiva.com.
법적 정보
MabSelect is a trademark of Cytiva
SuRe is a trademark of Cytiva
신호어
Warning
유해 및 위험 성명서
Storage Class Code
3 - Flammable liquids
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문서
This page describes efficient column packing and preparation for affinity chromatography of antibodies.
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