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Merck
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주요 문서

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G9048

Sigma-Aldrich

GANT61

≥98% (HPLC)

동의어(들):

2,2′-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl-benzenamine, NSC 136476

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About This Item

실험식(Hill 표기법):
C27H35N5
CAS Number:
500579-04-4
Molecular Weight:
429.60
MDL number:
MFCD14635408
UNSPSC 코드:
51111800
NACRES:
NA.77

분석

≥98% (HPLC)

양식

powder

색상

white to off-white

solubility

DMSO: >2 mg/mL

저장 온도

2-8°C

SMILES string

N2(C(N(CCC2)Cc4c(cccc4)N(C)C)c3ccncc3)Cc1c(cccc1)N(C)C

InChI

1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3

InChI key

KVQOGDQTWWCZFX-UHFFFAOYSA-N

관련 카테고리

생화학적/생리학적 작용

GANT61 blocks hedgehog pathway signaling by inhibiting the transcripional activity of Gli1 (IC50 = 5 μM). GANT 61 led to a regression of 22Rv1 human prostate tumor cell xenografts in nude mice.
GANT61 is a Hh pathway Gli Inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
026M4716V
035M4728V
024M4711V
053M4724V
011M4625V

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문서 라이브러리 방문

Syeda Kiran Riaz et al.
Frontiers in cell and developmental biology, 9, 758400-758400 (2021-11-02)
The underlying mechanism of fibroblast growth factor receptor 1 (FGFR1) mediated carcinogenesis is still not fully understood. For instance, FGFR1 upregulation leads to endocrine therapy resistance in breast cancer patients. The current study aimed to identify FGFR1-linked genes to devise
Syeda Kiran Riaz et al.
Scientific reports, 9(1), 6620-6620 (2019-05-01)
Sonic Hedgehog signaling is critical for breast morphogenesis and cancer. The present study was conducted to explore the influence of SHH/GLI1 axis on epithelial mesenchymal transition and invasion in breast cancer cells. SHH/GLI1 positive samples demonstrated high expression of Snail
Hong Zhang et al.
Journal of Cancer, 10(4), 990-1003 (2019-03-12)
Background: Accumulating evidence indicates that aberrant activation of the Hedgehog (Hh) signalling pathway by Glioma-associated oncogene (Gli) transcription factors is involved in the aggressive progression of cancers, including ovarian cancer. Whereas the molecular mechanism underlying this phenomenon remains unelucidated. Matrix
Deepika Neelakantan et al.
Nature communications, 8, 15773-15773 (2017-06-13)
Recent fate-mapping studies concluded that EMT is not required for metastasis of carcinomas. Here we challenge this conclusion by showing that these studies failed to account for possible crosstalk between EMT and non-EMT cells that promotes dissemination of non-EMT cells.
Liyao Xu et al.
International journal of oncology, 50(5), 1868-1878 (2017-04-11)
Multiple lines of evidence indicate that aberrant activation of Hedgehog (Hh) signaling plays an important role in tumorigenesis in human glioma. However, the underlying molecular mechanism and crucial downstream targets of glioma-associated oncogene (Gli), a primary transcriptional regulator of Hh signaling
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