추천 제품
재조합
expressed in baculovirus infected Sf9 cells
Quality Level
제품 라인
PRECISIO® Kinase
분석
≥70% (SDS-PAGE)
형태
buffered aqueous glycerol solution
특이 활성도
32-44 nmol/min·mg
분자량
~95 kDa
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... GRK5(2869)
일반 설명
GRK5 (G protein-coupled receptor kinase 5) belongs to the G-protein coupled receptor kinase family, and shows major expression in normal human heart. This protein contains a nuclear localization sequence and hence localizes in nucleus.
생화학적/생리학적 작용
GRK5 (G protein-coupled receptor kinase 5) controls the functions of catecholamines, which bind and activate β-adrenergic receptors, and have cardiac inotropic and chronotropic actions. It is responsible for the uncoupling from G protein by facilitating β1-adrenergic receptor phosphorylation and β-arrestin recruitment. This protein plays a key role in growth and metastasis in prostate cancer, where it phosphorylates moesin.† A genome-wide association study (GWAS) has shown that rs10886471 variant in GRK5 gene is linked with susceptibility to type 2 diabetes mellitus (T2DM).
물리적 형태
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
법적 정보
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Miklos D Kertai et al.
Circulation. Cardiovascular genetics, 7(5), 625-633 (2014-07-23)
We hypothesized that genetic variations in the adrenergic signaling pathway and cytochrome P450 2D6 enzyme are associated with new-onset atrial fibrillation (AF) in patients who underwent coronary artery bypass grafting and were treated with perioperative β-blockers (BBs). Two cohorts of
Zhenfang Xia et al.
PloS one, 9(3), e90597-e90597 (2014-03-07)
A genome-wide association study had showed G-protein-coupled receptor kinase 5 (GRK5) rs10886471 was related to the risk of type 2 diabetes mellitus (T2DM) through upregulated GRK5 mRNA expression. Rs10886471 is located in the intron region of GRK5. However, the mechanism
Prabir Kumar Chakraborty et al.
Cancer research, 74(13), 3489-3500 (2014-04-24)
G protein-coupled receptor kinases (GRK) regulate diverse cellular functions ranging from metabolism to growth and locomotion. Here, we report an important contributory role for GRK5 in human prostate cancer. Inhibition of GRK5 kinase activity attenuated the migration and invasion of
Jie Fan et al.
Nature medicine, 9(3), 315-321 (2003-02-20)
Polymorphonuclear leukocytes (PMNs) are critical effector cells of the innate immune system that protect the host by migrating to inflammatory sites and killing pathogenic microbes. We addressed the role of chemokine receptor desensitization induced by G-protein-coupled receptor kinases (GRKs) in
P Kunapuli et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(12), 5588-5592 (1993-06-15)
Guanine nucleotide binding protein (G-protein)-coupled receptor kinases (GRKs) specifically phosphorylate the agonist-occupied form of G-protein-coupled receptors such as the beta 2-adrenergic receptor and rhodopsin. The best characterized members of this family include the beta-adrenergic receptor kinase (beta ARK) and rhodopsin
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