G6025

Geranylgeranyl pyrophosphate ammonium salt

solution, ≥95% (TLC), ~1 mg/mL in methanol: NH₄OH (7:3)

• 동의어(들): GGPP, all trans-3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenyl pyrophosphate ammonium salt
• 실험식(Hill 표기법): C₂₀H₃₆O₇P₂ · xNH₃
• CAS Number: 6699-20-3
• Molecular Weight: 450.44 (free acid basis)
• MDL number: MFCD00156114
• UNSPSC 코드: 12352211
• PubChem Substance ID: 24895243
• NACRES: NA.77

속성

• 분석: ≥95% (TLC)
• 형태: solution
• 포장: vial of 200 μg
• 농도: ~1 mg/mL in methanol: NH₄OH (7:3)
• 저장 온도: −20°C
• SMILES string: C\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O
• InChI: 1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+,20-15+
• InChI key: OINNEUNVOZHBOX-QIRCYJPOSA-N

설명

애플리케이션

Geranylgeranyl pyrophosphate ammonium salt has been used:

• in the preparation of 2.5X reaction buffer for Rab GGTase assay
• to add to the culture to further drive Hmg2 degradation
• as a substrate to carryout in vitro enzymatic assays for the characterization of the prenyltransferases
• to reverse the action of lovastatin and also used to examine the potential role of GGPP in the study to assess the effects of exposing the melanoma cell lines in the angiogenesis model as a co-culture to lovastatin in vitro

생화학적/생리학적 작용

Geranylgeranyl pyrophosphate (GGPP) is a major enzyme that participates in the secondary metabolism of chloroplast. GGPP synthase plays a key role in the biosynthesis of terpenoid. Protein geranylgeranylation, mediated by geranylgeranyl pyrophosphate participates in the development of the ventricular chamber. It also serves as a stage-specific signal to modulate the formation of cardiac cytoarchitecture the time of mid-gestation.

Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular weight G proteins, including Ras. Intermediate in terpene biosynthesis.

특징 및 장점

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안전성 정보

• 픽토그램: GHS02,GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H225,H301 + H311 + H331,H370
• 예방조치 성명서: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 표적 기관: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point (°F): 51.8 °F - closed cup
• Flash Point (°C): 11 °C - closed cup
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter