G119

GYKI 52466 hydrochloride

solid

• 동의어(들): 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
• 실험식(Hill 표기법): C₁₇H₁₅N₃O₂ · HCl
• CAS Number: 192065-56-8
• Molecular Weight: 329.78
• MDL number: MFCD00153803
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277984
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 양식: solid
• 색상: yellow
• solubility: DMSO: 0.39 mg/mL; ethanol: 0.4 mg/mL; 0.1 M HCl: 0.68 mg/mL; methanol: 1 mg/mL; H₂O: >10 mg/mL
• SMILES string: Cl[H].CC1=NN=C(c2ccc(N)cc2)c3cc4OCOc4cc3C1
• InChI: 1S/C17H15N3O2.ClH/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11;/h2-5,7-8H,6,9,18H2,1H3;1H
• InChI key: RUBSCPARMVJNKX-UHFFFAOYSA-N
• 유전자 정보: human ... GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893)

설명

애플리케이션

GYKI 52466 hydrochloride has been used as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor selective antagonist in cell viability assays to evaluate the specificity of kainate (KA) effect on cerebellar granule cells (CGCs). It has also been used as an AMPA blocker to study the function of glutamate in neuroadapted sindbis virus (NSV) -induced motor neuron death.

생화학적/생리학적 작용

GYKI 52466 serves as an antagonist of several processes, mediated by glutamate.

Selective allosteric AMPA receptor antagonist; anti­convulsant; skeletal muscle relaxant.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

법적 정보

Sold under exclusive license from the Institute for Drug Research Ltd., Budapest, Hungary.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves