E0657
Monoclonal Anti-phospho-Epidermal Growth Factor Receptor (pTyr1068) antibody produced in mouse
clone 338324, purified immunoglobulin, lyophilized powder
동의어(들):
Monoclonal Anti-EGFR, Monoclonal Anti-ERBB, Monoclonal Anti-HER1, Monoclonal Anti-PIG61
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모든 사진(1)
About This Item
UNSPSC 코드:
12352203
NACRES:
NA.41
결합:
unconjugated
application:
FACS
WB
WB
클론:
338324, monoclonal
종 반응성:
human
citations:
3
기술:
flow cytometry: 5 μg/mL
western blot: 1 μg/mL
western blot: 1 μg/mL
추천 제품
생물학적 소스
mouse
Quality Level
결합
unconjugated
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
338324, monoclonal
양식
lyophilized powder
종 반응성
human
기술
flow cytometry: 5 μg/mL
western blot: 1 μg/mL
동형
IgG2a
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... EGFR(1956)
관련 카테고리
면역원
purified, synthetic phosphopeptide corresponding to residues surrounding tyrosine 1068 of human epidermal growth factor receptor.
생화학적/생리학적 작용
EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer. Tyr1068 is a minor autophosphorylation site and enables the binding of EGFR to GAB-1 or Grb2.
물리적 형태
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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관련 제품
제품 번호
설명
가격
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Fen Wang et al.
Journal of experimental & clinical cancer research : CR, 31, 65-65 (2012-08-21)
EGFR mutation is a strong predictive factor of EGFR-TKIs therapy. However, at least 10% of patients with EGFR wild-type are responsive to TKIs, suggesting that other determinants of outcome besides EGFR mutation might exist. We hypothesized that activation of phosphorylated
Jing Bai et al.
Asian Pacific journal of cancer prevention : APJCP, 13(10), 4879-4881 (2012-12-19)
Epidermal growth factor receptor (EGFR) overexpression is associated with resistance to chemotherapy and radiotherapy. The EGFR modulates DNA repair after radiation-induced damage through an association with the catalytic subunit of DNA protein kinase. DNA double-strand breaks (DSBs) are the most
Thu H Truong et al.
Biochemistry, 51(50), 9954-9965 (2012-11-29)
Epidermal growth factor receptor (EGFR) exemplifies the family of receptor tyrosine kinases that mediate numerous cellular processes, including growth, proliferation, and differentiation. Moreover, gene amplification and EGFR mutations have been identified in a number of human malignancies, making this receptor
Ming Qian et al.
Oncology reports, 32(4), 1681-1688 (2014-10-21)
The aim of the present study was to evaluate the potency of epidermal growth factor receptor (EGFR) pathway inhibition achieved by combining cetuximab (CET), an anti-EGFR monoclonal antibody, and celecoxib (CXB), a cyclooxygenase-2 (COX-2) inhibitor, in oral squamous cell carcinoma
Javier Palazuelos et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 11884-11896 (2014-09-05)
Several studies have elucidated the significance of a disintegrin and metalloproteinase proteins (ADAMs) in PNS myelination, but there is no evidence if they also play a role in oligodendrogenesis and CNS myelination. Our study identifies ADAM17, also called tumor necrosis
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