추천 제품
생물학적 소스
synthetic
분석
≥98% (TLC)
양식
powder
mp
205 °C
solubility
water: 50 mg/mL, clear, colorless
저장 온도
−20°C
SMILES string
Cl[H].N[C@@H](CCl)C(O)=O
InChI
1S/C3H6ClNO2.ClH/c4-1-2(5)3(6)7;/h2H,1,5H2,(H,6,7);1H/t2-;/m0./s1
InChI key
IENJPSDBNBGIEL-DKWTVANSSA-N
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애플리케이션
β-Chloro-L-alanine hydrochloride has been used:
- as a substrate for screening tyrosine phenol lyase steady state kinetics
- in the inhibition of serine palmitoyltransferase and cytotoxicity studies in lymphocyte Ly-1 cells
- as an inhibitor of alanine transaminase in wheat germ cell-free protein synthesis system
생화학적/생리학적 작용
β-Chloro-L-alanine hydrochloride is an inhibitor of alanine aminotransferase (ALAT). Inhibition of ALAT leads to suppression of tumor progression in lung carcinoma.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
Serine 51 residue of Citrobacter freundii tyrosine phenol-lyase assists in C-alpha-proton abstraction and transfer in the reaction with substrate
Barbolina MV, et al.
Biochimie, 147(1), 63-69 (2018)
Oxytetracycline have the therapeutic efficiency in CD133+ HCC population through suppression CD133 expression by decreasing of protein stability of CD133
Song Y, et al.
Scientific Reports, 8(1), 16100-16100 (2018)
Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells: a novel evaluation system using an SPT-defective mammalian cell mutant
Hanada K, et al.
Biochemical Pharmacology, 59(10), 1211-1216 (2000)
A novel way of amino acid-specific assignment in 1 H-15 N HSQC spectra with a wheat germ cell-free protein synthesis system
Morita EH, et al.
Journal of Biomolecular Nmr, 30(1), 37-45 (2004)
Inhibition of alanine aminotransferase (ALAT) in silico and in vivo promotes mitochondrial metabolism to impair malignant growth
Beuster G, et al.
The Journal of Biological Chemistry, jbc-M110 (2011)
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