C3865

Anti-N-Cadherin antibody, Mouse monoclonal

clone GC-4, purified from hybridoma cell culture

• 동의어(들): Anti-A-CAM, Anti-A-Cell Adhesion Molecule
• MDL number: MFCD00164511
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: GC-4, monoclonal
• 형태: buffered aqueous solution
• 분자량: antigen 135 kDa
• 종 반응성: chicken, monkey, mouse, human, rabbit, rat
• 기술: electron microscopy: suitable; flow cytometry: suitable; immunocytochemistry: suitable; immunohistochemistry: 10-20 μg/mL using rat cardiac muscle frozen sections; western blot: 10-20 μg/mL using chicken cardiac muscle or COS-7 cell extracts
• 동형: IgG1
• UniProt 수납 번호: P19022
• 응용 분야: research pathology
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CDH2(1000) ; mouse ... Cdh2(12558) ; rat ... Cdh2(83501)

설명

일반 설명

N-Cadherin is a member of the cadherin family of proteins that mediate cell-cell adhesion in a calcium dependent manner. N-cadherin is a transmembrane glycoprotein that localizes in the cell-cell adherens junction on the plasma membrane. The protein is known to be localized in the cell membrane.

애플리케이션

Anti-N-Cadherin antibody is suitable for the following procedures:

• electron microscopy
• flow cytometry
• immunocytochemistry
• immunohistochemistry at a concentration of 10-20μg/mL using rat cardiac muscle frozen sections
• western blot at a concentration of 10-20μg/mL using chicken cardiac muscle or COS-7 cell extracts

생화학적/생리학적 작용

CDH11 gene encodes a type II classical cadherin that mediate calcium-dependent cell-cell adhesion.

Higher expression of CDH2 gene was observed in tumor cells. It is known to induce the invasive and chemoresistant attributes to the cancer cells. N-glycosylation of N-cadherin is associated with the process of tumorigenesis especially in mammary gland, renal system, and ovary. Loss of expression of the gene was observed in adrenocortical carcinoma.

물리적 형태

0.2 μm-filtered solution in 0.01 M phosphate buffered saline, pH 7.4.

기타 정보

Clone GC-4 is also known as GB-9.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves