C3144

Coenzyme A sodium salt hydrate

cofactor for acyl transfer

• 동의어(들): CoA Na₂
• 실험식(Hill 표기법): C₂₁H₃₆N₇O₁₆P₃S · xNa⁺ · yH₂O
• CAS Number: 55672-92-9
• Molecular Weight: 767.53 (anhydrous free acid basis)
• EC Number: 259-747-8
• MDL number: MFCD00079020
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24892587
• NACRES: NA.51

속성

• 설명: cofactor for acyl transfer
• Quality Level: 200
• 분석: ≥85% (spectrophotometric assay)
• 양식: powder
• solubility: H₂O: soluble 50 mg/mL, clear, colorless to faintly yellow
• 저장 온도: −20°C
• SMILES string: [Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
• InChI key: SYTRWOCXZXQBPW-CLVRNSBASA-M

설명

일반 설명

Coenzyme A (CoA) is an essential cofactor in living systems and is synthesized from pantothenic acid (vitamin B5), The CoA levels in mitochondria and peroxisomes correspond to 2-5 mM and 0.7 mM, respectively. Cytosolic CoA is in the range of 0.05 mM to 0.14 mM

애플리케이션

Coenzyme A is suitable for use in:

• gylcerolipid biosynthesis in porcine adipose tissue
• an assay to measure the level of Alpha-methylacyl-CoA racemase (AMACR) in human blood samples using a nanoparticle electrochemical biosensor
• chloramphenicol acetyltransferase (CAT) assay
• the synthesis of palmitoyl-CoA, which is required for palmitoylation and activation of proteins for regulated membrane fusion

생화학적/생리학적 작용

Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes. In the presence of CoASH, organic carboxylic acids form acyl-CoA thioesters, which facilitates enzyme recognition. The acyl-CoA formed from xenobiotic carboxylic acids can add to the compound′s toxicity, which can lead to cellular metabolic dysfunction. It is involved in the oxidation of pyruvate in the Kreb′s cycle. CoA is needed for metabolic events. The bacterial CoA pathway is targeted for antimicrobial development. It mediates acyl group transfer and carbonyl activation. The CoA and its thioester levels are crucial for cellular homeostasis. CoA is also involved in regulating platelet aggregation and vasoconstriction. It acts as an essential cofactor in enzymatic acetyl transfer reactions.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)