C1335

S-(−)-Carbidopa

≥98% (TLC), powder

• 동의어(들): (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid, S-(−)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid
• 실험식(Hill 표기법): C₁₀H₁₄N₂O₄
• CAS Number: 28860-95-9
• Molecular Weight: 226.23
• EC Number: 249-271-9
• MDL number: MFCD00069231
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24892402
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥98% (TLC)
• 형태: powder
• solubility: methanol and 1 drop HCl: 4.90-5.10 mg/mL, clear, colorless to faintly yellow
• 저장 온도: −20°C
• SMILES string: CC(Cc1ccc(O)c(O)c1)(NN)C(O)=O
• InChI: 1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1
• InChI key: TZFNLOMSOLWIDK-JTQLQIEISA-N
• 유전자 정보: human ... DDC(1644)

설명

일반 설명

Carbidopa is used for treating restless legs (RL) syndrome and periodic leg movements in sleep (PLMS). Carbidopa along with levodopa is used to treat Parkinson′s disease.

생화학적/생리학적 작용

Peripheral inhibitor of L-aromatic amino acid decarboxylase. When co-administered with L-DOPA, it prevents extra-CNS conversion to dopamine, thereby increasing CNS concentrations of effective compounds. Selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells by increasing H₂O₂ in these cell lines, which are sensitive to reactive oxygen species.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)