모든 사진(1)
About This Item
실험식(Hill 표기법):
C31H45N7O7
CAS Number:
Molecular Weight:
627.73
MDL number:
UNSPSC 코드:
12352204
PubChem Substance ID:
NACRES:
NA.32
추천 제품
분석
≥98% (TLC)
Quality Level
양식
powder
solubility
water: 20 mg/mL, clear, colorless
저장 온도
−20°C
SMILES string
Cl.CC(C)C(NC(=O)OC(C)(C)C)C(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
InChI
1S/C31H45N7O7.ClH/c1-17(2)25(37-30(43)45-31(4,5)6)28(42)38-14-8-10-22(38)27(41)36-21(9-7-13-34-29(32)33)26(40)35-19-11-12-20-18(3)15-24(39)44-23(20)16-19;/h11-12,15-17,21-22,25H,7-10,13-14H2,1-6H3,(H,35,40)(H,36,41)(H,37,43)(H4,32,33,34);1H
InChI key
ROQGJTZGLVLVIN-UHFFFAOYSA-N
일반 설명
Boc-Val-Pro-Arg-AMC serves as a synthetic substrate for human kallikrein 8.
애플리케이션
Boc-Val-Pro-Arg-7-amido-4-methylcoumarin hydrochloride has been used:
- as a fluorogenic substrate for thrombin in inhibitory assay with salivary protein cE5
- as a fluorogenic substrate for thrombin in inhibitory assay with recombinant E. nipponicum serpin
- as a substrate in proteinase assay with hemolymph protein
포장
Bottomless glass bottle. Contents are inside inserted fused cone.
기질
A fluorogenic substrate for thrombin.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
Tadaaki Kishi et al.
Biological chemistry, 387(6), 723-731 (2006-06-28)
Human kallikrein 8 (hK8), whose gene was originally cloned as the human ortholog of a mouse brain protease, is known to be associated with diseases such as ovarian cancer and Alzheimer's disease. Recombinant human pro-kallikrein 8 was activated with lysyl
Luciano Pirone et al.
The Journal of biological chemistry, 292(30), 12632-12642 (2017-06-09)
Saliva of blood-feeding arthropods carries several antihemostatic compounds whose physiological role is to facilitate successful acquisition of blood. The identification of novel natural anticoagulants and the understanding of their mechanism of action may offer opportunities for designing new antithrombotics disrupting
Jantiwan Sutthangkul et al.
The Journal of biological chemistry, 290(10), 6470-6481 (2015-01-13)
The melanization cascade, activated by the prophenoloxidase (proPO) system, plays a key role in the production of cytotoxic intermediates, as well as melanin products for microbial sequestration in invertebrates. Here, we show that the proPO system is an important component
T Morita et al.
Journal of biochemistry, 82(5), 1495-1498 (1977-11-01)
Twenty peptide-4-methylcoumarin amides (MCA) were newly synthesized and tested as possible substrates for alpha-thrombin, factor Xa, kallikreins, urokinase, and plasmin. These fluorogenic peptides contained arginine-MCA as the carboxyl-terminus. Release of 7-amino-4-methylcoumarin was determined fluorometrically. Of these peptides, the following were
Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates.
R Lottenberg et al.
Methods in enzymology, 80 Pt C, 341-361 (1981-01-01)
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