B9285

5-Bromo-2′-deoxyuridine

BioUltra, ≥99%

• 동의어(들): 5-BrdU, 5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uracil, 5-Bromouracil deoxyriboside, BUdR
• 실험식(Hill 표기법): C₉H₁₁BrN₂O₅
• CAS Number: 59-14-3
• Molecular Weight: 307.10
• Beilstein: 30395
• EC Number: 200-415-9
• MDL number: MFCD00006529
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24892132
• NACRES: NA.51

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 제품 라인: BioUltra
• 분석: ≥99%
• 형태: powder
• 불순물: ≤0.005% Phosphorus (P); ≤0.1% Insoluble matter
• 무기 잔류물: ≤0.1%
• mp: 191-194 °C (dec.) (lit.)
• solubility: NH₄OH: 0.1 M at 20 °C, clear, colorless
• 양이온 미량물: Al: ≤0.0005%; Ca: ≤0.01%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.05%; Pb: ≤0.001%; Zn: ≤0.0005%
• 저장 온도: −20°C
• SMILES string: OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(Br)C(=O)NC2=O
• InChI: 1S/C9H11BrN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
• InChI key: WOVKYSAHUYNSMH-RRKCRQDMSA-N

설명

일반 설명

5′-Bromo-2-deoxyuridine (BrdU) is a carcinogen that may be absorbed by skin or inhalation. BrdU solutions are sensitive to light.

애플리케이션

5-Bromo-2′-deoxyuridine has been used:

• to label proliferating cells in pregnant mice in cell proliferation assay
• to study the time course of cell proliferation at various times following ischemia, to confirm re-entry of MKI67+ cells in cell cycle to germ cells
• in 5′-Bromo-2′Deoxyuridine (BrdUrd) staining of fibroblasts

생화학적/생리학적 작용

5′-Bromo-2-deoxyuridine (BrdU) staining is predominantly used to observe the multiplication of tumor cells and other tissues in vivo.

5-Bromo-2′-deoxyuridine (5-BrdU) is a thymidine analogue which is incorporated into DNA. 5-BrdU is routinely and extensively used to measure DNA synthesis and to label dividing cells. Consequently 5-BrdU is used to study cell signaling and other processes that induce cell proliferation.

Thymidine analog used as a mutagen in genetic research. Selectively incorporated into cellular DNA during S-phase.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H340,H361fd
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 1B - Repr. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)