추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
종 반응성
human, rat, mouse
농도
~1 mg/mL
기술
immunohistochemistry: 1:100-1:250
western blot: 1:500-1:1,000
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
관련 카테고리
일반 설명
Brachyury (T) is an oncogene mapped to human chromosome 6q27. This gene codes for Brachyury, which is expressed throughout the primary mesoderm during the early stages of embryogenesis. Brachyury protein structure comprises highly conserved DNA binding domain, known as T-box domain.
면역원
synthetic peptide corresponding to an internal sequence of human brachyury (GeneID 6862). This sequence is 80% identical in mouse and 86% identical in rat.
생화학적/생리학적 작용
Brachyury protein is a transcription factor that aids in the embryonic development of notochord tissue. It also plays an essential role in posterior mesoderm formation and differentiation. Brachyury is highly expressed in a variety of cancers including, chordoma and hemangioblastoma. It serves as an immunohistochemical marker for differential diagnosis of chordoma and hemangioblastoma (HBL).
물리적 형태
Solution in phosphate buffered saline containing 0.02% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Scott W Connors et al.
F1000Research, 9 (2020-07-30)
Chordomas are rare and difficult-to-treat tumors arising from the embryonic notochord. While surgery is the mainstay of treatment, and despite new techniques aimed at maximizing total tumoral resection, recurrence remains high and the probability of disease-free survival low. New breakthroughs
Jianjian Zhu et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(14), 3820-3825 (2016-03-24)
The transcription factor Brachyury (T) gene is expressed throughout primary mesoderm (primitive streak and notochord) during early embryonic development and has been strongly implicated in the genesis of chordoma, a sarcoma of notochord cell origin. Additionally, T expression has been
Haibo Wu et al.
Cell death & disease, 8(7), e2953-e2953 (2017-07-28)
MicroRNAs (miRNAs) regulate critical cell processes, such as apoptosis, proliferation, and development. However, the role of miRNAs in embryonic stem cell (ESC) neural differentiation induced by retinoic acid (RA) and factors that govern neural directional differentiation remain poorly understood. In
Charles T Foster et al.
Molecular and cellular biology, 30(20), 4851-4863 (2010-08-18)
Lysine-specific demethylase 1 (LSD1), which demethylates mono- and dimethylated histone H3-Lys4 as part of a complex including CoREST and histone deacetylases (HDACs), is essential for embryonic development in the mouse beyond embryonic day 6.5 (e6.5). To determine the role of
Filipe Pinto et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(18), 4949-4961 (2014-07-11)
Successful therapy of patients with prostate cancer is highly dependent on reliable diagnostic and prognostic biomarkers. Brachyury is considered a negative prognostic factor in colon and lung cancer; however, there are no reports on Brachyury's expression in prostate cancer. In
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