B8279

Ro-20-1724

≥98% (HPLC), solid, cAMP phosphodiesterase inhibitor

• 동의어(들): Ro 20-1724
• 실험식(Hill 표기법): C₁₅H₂₂N₂O₃
• CAS Number: 29925-17-5
• Molecular Weight: 278.35
• MDL number: MFCD00077397
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24278195
• NACRES: NA.77

속성

• 제품명: 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one, solid
• 생물학적 소스: synthetic (organic)
• 분석: ≥98% (HPLC)
• 양식: solid
• solubility: ethanol: 7 mg/mL; H₂O: insoluble
• 저장 온도: room temp
• SMILES string: CCCCOc1cc(CC2CNC(=O)N2)ccc1OC
• InChI: 1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)
• InChI key: PDMUULPVBYQBBK-UHFFFAOYSA-N
• 유전자 정보: human ... LITAF(9516) , PDE4B(5142) , PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577) ; rat ... Pde4a(25638)

설명

애플리케이션

4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one has been used:

• as a cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitor to treat cells for the determination of intracellular cAMP levels
• as a component of serum-free medium
• as phosphodiesterase inhibitor in order to study the effects of protease-activated receptor-1 (PAR-1) activation on cAMP levels

생화학적/생리학적 작용

Inhibitor of cAMP phosphodiesterase. IC₅₀ 33 μM in vascular smooth muscle of the aorta.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves