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Merck
모든 사진(1)

주요 문서

B7632

Sigma-Aldrich

N-Benzoyl-Phe-Val-Arg-p-nitroanilide hydrochloride

chromogenic, protease substrate, ≥98% (TLC), powder

동의어(들):

N-Benzoyl-L-phenylalanyl-L-valyl-L-arginine-4-nitroanilide hydrochloride

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About This Item

실험식(Hill 표기법):
C33H40N8O6 · HCl
CAS Number:
Molecular Weight:
681.18
Beilstein:
3027332
MDL number:
UNSPSC 코드:
12352204
PubChem Substance ID:
NACRES:
NA.32

제품명

N-Benzoyl-Phe-Val-Arg-p-nitroanilide hydrochloride, protease substrate

분석

≥98% (TLC)

양식

powder

solubility

methanol: 20 mg/mL, clear, colorless to light yellow

저장 온도

−20°C

SMILES string

Cl.CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc3ccc(cc3)[N+]([O-])=O

InChI

1S/C33H40N8O6.ClH/c1-21(2)28(40-31(44)27(20-22-10-5-3-6-11-22)39-29(42)23-12-7-4-8-13-23)32(45)38-26(14-9-19-36-33(34)35)30(43)37-24-15-17-25(18-16-24)41(46)47;/h3-8,10-13,15-18,21,26-28H,9,14,19-20H2,1-2H3,(H,37,43)(H,38,45)(H,39,42)(H,40,44)(H4,34,35,36);1H/t26-,27-,28-;/m0./s1

InChI key

PYVSMZDQQUZGPF-JAQKLANPSA-N

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일반 설명

N-Benzoyl-Phe-Val-Arg-p-nitroanilide is a chromogenic protease substrate.

애플리케이션

  • N

  • -Benzoyl-Phe-Val-Arg-p-nitroanilide hydrochloride has been used: as a substrate: for trypsin-like enzyme in the soluble and particulate fractions of the hyphae
  • for the thrombin, recombinant and native batroxobin from snake venom
  • for fibrinolytic enzyme aprE2 in amidolytic activity assay

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

기질

A substrate for trypsin, thrombin and reptilase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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시험 성적서(COA)

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문서 라이브러리 방문

Inhibition of human coagulation factor Xa by thrombin substrates.
C L Orthner et al.
Thrombosis research, 23(6), 533-539 (1981-09-15)
Heparin and protease inhibition. II. The role of heparin in the ATIII inactivation of thrombin, plasmin, and trypsin.
G F Smith et al.
Thrombosis research, 22(1-2), 115-133 (1981-04-01)
Synthesis of Bz-Phe(p-No2)-Val-Arg-pNA-and its specificity to thrombin-like enzymes: similarity of a commercial product S-2160 to the nitrated compound.
K Takada et al.
Thrombosis research, 20(5-6), 533-572 (1980-12-01)
Hydrolysis of N-alpha-benzoyl-L-phenylalanyl-L-valyl-L-arginine-p-nitroanilide by human alpha thrombin in the presence of heparin.
M J Griffith et al.
Thrombosis research, 17(1-2), 83-90 (1980-01-01)
Y Komori et al.
Biochimica et biophysica acta, 829(1), 127-130 (1985-05-20)
Hemorrhagic proteinase, HTb, isolated from Crotalus atrox (western diamondback rattlesnake) venom was studied for its specificity. HTb showed fibrinogenase activity, hydrolyzing the A alpha chain of fibrinogen first, followed by the cleavage of the B beta chain. HTb is different

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