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Merck
모든 사진(1)

주요 문서

B6769

Sigma-Aldrich

des-Arg9-[Leu8]-Bradykinin acetate salt

≥97% (HPLC)

동의어(들):

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Leu

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About This Item

실험식(Hill 표기법):
C41H63N11O10
CAS Number:
Molecular Weight:
870.01
MDL number:
UNSPSC 코드:
12352209
PubChem Substance ID:
NACRES:
NA.26

제품명

des-Arg9-[Leu8]-Bradykinin acetate salt, ≥97% (HPLC)

Quality Level

분석

≥97% (HPLC)

양식

powder

색상

white

저장 온도

−20°C

SMILES string

CC(O)=O.CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(O)=O

InChI

1S/C41H63N11O10.C2H4O2/c1-24(2)20-28(40(61)62)48-36(57)31-14-8-17-50(31)38(59)29(23-53)49-34(55)27(21-25-10-4-3-5-11-25)47-33(54)22-46-35(56)30-13-7-18-51(30)39(60)32-15-9-19-52(32)37(58)26(42)12-6-16-45-41(43)44;1-2(3)4/h3-5,10-11,24,26-32,53H,6-9,12-23,42H2,1-2H3,(H,46,56)(H,47,54)(H,48,57)(H,49,55)(H,61,62)(H4,43,44,45);1H3,(H,3,4)/t26-,27-,28-,29-,30-,31-,32-;/m0./s1

InChI key

XBFMNOKHQZCARQ-XXZMQFNDSA-N

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Leu

애플리케이션

The Bradkykinin amid peptide des-Arg9-[Leu8]-Bradykinin is used as a bradykinin-1 receptor (B1R) antagonist frequently in comparison with the B1 receptor agonist des-Arg9-bradykinin.

생화학적/생리학적 작용

Bradykinin receptor antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

M M Campos et al.
British journal of pharmacology, 117(5), 793-798 (1996-03-01)
1. The effect of pretreatment with bacterial endotoxin (LPS, 10 micrograms, i.v., 24 h) on the bradykinin B1 and B2 receptor-induced oedema in the rat paw, and the interaction of B1-mediated responses with other inflammatory mediators, was investigated. 2. Intraplantar
Juliano Ferreira et al.
Neuropharmacology, 54(3), 597-604 (2008-01-01)
The peripheral injection of phorbol myristate acetate (PMA) into the mouse paw induces nociception mediated through activation of protein kinase C (PKC). In the present study, we examine the contribution of kinin B1 receptor to PMA-induced nociception. Nociception was assessed
Thomas A Barker et al.
Hypertension (Dallas, Tex. : 1979), 48(5), 942-949 (2006-09-20)
It has been suggested that the effects of angiotensin II type 1 receptor (AT1R) blockers are in part because of angiotensin II type 2 receptor (AT2R) signaling. Interactions between the AT2R and kinins modulate cardiovascular function. Because AT2R expression increases

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