A9525

Angiotensin II human

≥93% (HPLC), powder

• 동의어(들): 1-8-AngiotensinI, 5-Isoleucine-angiotensinII, Ang II, Angiotensin 2, Angiotensin II, DRVYIHPF, Hypertensin, Ile(5)-angiotensinII
• 실험식(Hill 표기법): C₅₀H₇₁N₁₃O₁₂
• CAS Number: 4474-91-3
• Molecular Weight: 1046.18
• MDL number: MFCD00161484
• UNSPSC 코드: 12352202
• eCl@ss: 42020611
• PubChem Substance ID: 24891466
• NACRES: NA.32

속성

• 생물학적 소스: synthetic
• Quality Level: 300
• 분석: ≥93% (HPLC)
• 양식: powder
• 저장 조건: (Keep container tightly closed in a dry and well-ventilated place)
• 농도: ≤100%
• 기술: cell culture | mammalian: suitable
• 불순물: 1.2-10.4% acetate
• solubility: water: 25 mg/mL, clear, colorless
• UniProt 수납 번호: P01019
• 저장 온도: −20°C
• SMILES string: [nH]1cncc1C[C@H](NC(=O)C(NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)CCCNC(=N)N)C(C)C)Cc4ccc(cc4)O)[C@H](CC)C)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](Cc3ccccc3)C(=O)O
• InChI: 1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1
• InChI key: CZGUSIXMZVURDU-GYGDIBSWSA-N
• 유전자 정보: human ... AGT(183)

설명

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

일반 설명

Research area: Cell Signaling

애플리케이션

• Angiotensin II (angII) human has been used:
• to study its effect on interleukin-1β–mediated islet inflammation and β-cell dysfunction.
• to determine if angII activates specific calcineurin-dependent NFAT (nuclear factor of activated T-cells) isoforms in cardiomyocytes.
• to study the actions of systemic angII infusions on glomerular permeability in vivo.
• to induce abdominal aortic aneurysms (AAAs) in ApoE knockout mice for experimental studies.
• to study the effect of Ang II infusion on atrial branched-chain amino acids (BCAAs) catabolism in male C57/BL6 mice.
• to check the effects of angII on plasma triglyceride production and its association with insulin resistance in normal rats.

생화학적/생리학적 작용

Angiotensin II (angII) is an octapeptide cardiovascular hormone which affects the activities of the heart, kidney, vasculature and brain. AngII in the blood is produced from angiotensinogen via renin and angiotensin converting enzyme (ACE). It works via binding to specific receptors present on cell membranes. It is associated with vasoconstriction, induction of vascular smooth muscle cell growth, stimulation of protooncogene expression, and modulation of myocardial hypertrophy, renal failure and fibrosisAngII plays a key role in the regulation of blood pressure via the renin-angiotensin-aldosterone (RAAS) pathway.

특징 및 장점

The purity of our angiotensin II human, Ang II, is verified to assure your experimental success (HPLC and peptide content). The peptide sequence is DRVYIHPF.

항체 흡착제

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH · 2CH₃COOH · H₂O

분석 메모

Peptide content not less than 75%

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)