B178

Butein

solid

• 동의어(들): 1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one, 2′,3,4,4′-Tetrahydroxychalcone
• 실험식(Hill 표기법): C₁₅H₁₂O₅
• CAS Number: 487-52-5
• Molecular Weight: 272.25
• EC Number: 207-659-5
• MDL number: MFCD00017300
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24891611
• NACRES: NA.77

속성

• 양식: solid
• 색상: yellow
• solubility: DMSO: >50 mg/mL; H₂O: insoluble
• SMILES string: OC1=CC(O)=C(C(/C=C/C2=CC(O)=C(O)C=C2)=O)C=C1
• InChI: 1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+
• InChI key: AYMYWHCQALZEGT-ORCRQEGFSA-N
• 유전자 정보: rat ... Alox5(25290)

설명

일반 설명

Butein (2′,3,4,4′-tetrahydroxychalcone) is a chalcone and a flavonoid, that is produced in plants. It is a plant polyphenol and a bioactive constituent, that is extracted from the heartwood of Dalbergia odorifera, Caragana jubata and Rhus verniciflua stokes, and the stem bark of cashews (Semecarpus anacardium).

생화학적/생리학적 작용

Butein exhibit several pharmacological activities, such as anti-oxidant and anti-inflammatory activity. It stimulates apoptotic cell death of human cervical cancer cells. It has therapeutic potentials for chronic diseases, including liver tuberculosis, obesity, diabetes and hypertension. Butein can repress migration and invasion of bladder, breast and pancreatic cancer cells.

Inhibits EGFR and Src tyrosine kinase activities; inhibits cAMP-dependent PDE-IV. Induces apoptosis in B16 melanoma cells and HL-60 human leukemia cells.

특징 및 장점

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주의사항

Photosensitive

안전성 정보

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)