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Merck
모든 사진(2)

Key Documents

AV45599

Sigma-Aldrich

Anti-NR3C2 antibody produced in rabbit

IgG fraction of antiserum

동의어(들):

Anti-MCR, Anti-MGC133092, Anti-MLR, Anti-MR, Anti-Nuclear receptor subfamily 3, group C, member 2

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

IgG fraction of antiserum

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

107 kDa

종 반응성

human, rabbit

농도

0.5 mg - 1 mg/mL

기술

immunohistochemistry: suitable
western blot: suitable

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... NR3C2(4306)

관련 카테고리

일반 설명

Mineralocorticoid receptor/nuclear receptor subfamily 3, group C, member 2/ (NR3C2, MLR, MCR) is a nuclear receptor for mineralocorticoids (eg. aldosterone) and glucocorticoids (eg. cortisol) that activates expression of proteins involved with ionic (salt balance) and water transport such as the epithelial sodium channel, Na+/K+ pump and serum and glucocorticoid induced kinase (SGK1).

특이성

Anti-NR3C2 polyclonal antibody reacts with chicken, human, mouse, and rat mineralocorticoid/ aldosterone receptors.

면역원

Synthetic peptide directed towards the middle region of human NR3C2

애플리케이션

Anti-NR3C2 polyclonal antibody is used to tag mineralocorticoid receptor protein for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of mineralocorticoid receptor in the mineralocorticoid and glucocorticoid ligand-dependent control of salt balance and water retention.

생화학적/생리학적 작용

NR3C2 is a receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. It binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.

서열

Synthetic peptide located within the following region: RRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPP

물리적 형태

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Aidong Chen et al.
The Journal of physiology, 592(16), 3523-3536 (2014-06-29)
Circulating Ang II activates an aldosterone-mineralocorticoid receptor (MR) - angiotensin II (Ang II) - angiotensin type 1 receptor (AT1R) pathway in the hypothalamus. To obtain insights into the actual neuronal projections involved, adeno-associated virus carrying small interfering RNA against either

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