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Merck
모든 사진(2)

주요 문서

A5106

Sigma-Aldrich

Anti-ABI1 antibody produced in rabbit

enhanced validation

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

동의어(들):

Anti-Abelson interactor 1, Anti-Abl-interactor protein 1, Anti-Nap1 binding protein NAP1BP, Anti-eps8 binding protein, Anti-interactor protein AblBP4, Anti-spectrin SH3 domain binding protein 1 SSH3BP1

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41
결합:
unconjugated
application:
WB
클론:
polyclonal
종 반응성:
human, canine (predicted), mouse (predicted), rat
citations:
16
기술:
western blot: 0.5-1.0 μg/mL using A431 cell lysate
western blot: 0.5-1.0 μg/mL using extract of rat brain cytosolic fraction (S1)

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

분자량

antigen ~65 kDa

종 반응성

human, canine (predicted), mouse (predicted), rat

향상된 검증

recombinant expression
Learn more about Antibody Enhanced Validation

농도

~1.5 mg/mL

기술

western blot: 0.5-1.0 μg/mL using A431 cell lysate
western blot: 0.5-1.0 μg/mL using extract of rat brain cytosolic fraction (S1)

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... ABI1(10006)
mouse ... Abi1(11308)
rat ... Abi1(79249)

일반 설명

Abelson interactor 1 (Abi1) protein, a 65 kD-substrate of the eponymous Abelson non-receptor tyrosine kinase (c-Abl) is expressed mainly in the central nervous system. This gene is located on human chromosome 10p12.
Abi 1 is an adaptor protein that interacts with Wave2 to regulate actin polymerization.

면역원

synthetic peptide corresponding to amino acids 163-180 of human ABI1, conjugated to KLH. The corresponding sequence is identical in several species including mouse, rat, and dog.

애플리케이션

Anti-ABI1 antibody produced in rabbit has been used in western blot analysis and immunofluorescence.
Rabbit anti- ABI1 antibody can be used for immunoblotting assays at a concentration of 0.5-1.0μg/ml using extracts from A431 and rat brain cells.

생화학적/생리학적 작용

Abelson interactor 1 (Abi1) is essential for the formation and activation of WAVE2 signaling complex. ABI1 and WAVE are essential for Rac-dependent membrane protrusion and macropinocytosis, whereas ABI1 and N-WASP regulate actin-based vesicular transport, EGF receptor endocytosis, and EGFR and transferrin receptor (TfR) cell surface distribution. ABI1 has been shown to act as dual regulator of WAVE and neural Wiskott-Aldrich syndrome protein (N-WASP) specific activities. ABI1 is an essential component of this signaling complex. It positively regulates WAVE activity and connects WAVE to Rac through assembly of the WAVE-ABI1-Nap1-PIR121 complex. Abi1 modulates actin reorganization and lamellipodia formation.

물리적 형태

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Decreased expression of cortactin in schizophrenia brain
Bhambhvani HP, et al.
Neuroreport, 27(3), 145-145 (2016)
ENL, the MLL fusion partner in t (11; 19), binds to the c-Abl interactor protein 1 (ABI1) that is fused to MLL in t (10; 11)+
Garcia-Cuellar MP, et al.
Oncogene, 19(14), 1744-1744 (2000)
Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes
Innocenti M, et al.
Nature Cell Biology, 7(10), 969-976 (2005)
Hriday P Bhambhvani et al.
Neuroreport, 27(3), 145-150 (2015-12-23)
Schizophrenia is a severe psychiatric disorder that is characterized by a wide array of symptoms and a complex neuropathology. A well-characterized neurobiological feature of schizophrenia is abnormal synaptic plasticity, although the mechanisms underlying this are not fully understood. Numerous studies
Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells
Steinestel K, et al.
Molecular Cancer, 13(1), 145-145 (2014)

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