A3940

1-Aminobenzotriazole

≥98% (TLC), powder, cytochrome P450 inhibitor

• 동의어(들): 1-Benzotriazolamine, ABT
• 실험식(Hill 표기법): C₆H₆N₄
• CAS Number: 1614-12-6
• Molecular Weight: 134.14
• Beilstein: 607843
• MDL number: MFCD00132902
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278226
• NACRES: NA.77

속성

• product name: 1-Aminobenzotriazole,
• 분석: ≥98% (TLC)
• Quality Level: 200
• 형태: powder
• 환경친화적 대안 제품 점수: old score: 93; new score: 46; Find out more about DOZN™ Scoring
• 환경친화적 대안 제품 특성: Waste Prevention; Safer Solvents and Auxiliaries; Inherently Safer Chemistry for Accident Prevention; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• mp: 81-84 °C (lit.)
• solubility: ethanol: 49-51 mg/mL, clear, pale yellow to yellow
• 환경친화적 대안 카테고리: , Re-engineered
• SMILES string: Nn1nnc2ccccc12
• InChI: 1S/C6H6N4/c7-10-6-4-2-1-3-5(6)8-9-10/h1-4H,7H2
• InChI key: JCXKHYLLVKZPKE-UHFFFAOYSA-N
• 유전자 정보: human ... CYP1A2(1544)

설명

일반 설명

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives. This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Safer Solvents and Auxiliaries” and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

애플리케이션

1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H₂O₂-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.

생화학적/생리학적 작용

1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.

Suicide inhibitor of cytochrome P450 and chloroperoxidase.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves