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Merck
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주요 문서

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A2251

Sigma-Aldrich

Acetyl-β-methylcholine chloride

≥98% (TLC), powder

동의어(들):

(2-Acetoxypropyl)trimethylammonium chloride, Methacholine chloride

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모든 사진(3)

About This Item

Linear Formula:
CH3COOCH(CH3)CH2N(Cl)(CH3)3
CAS Number:
62-51-1
Molecular Weight:
195.69
Beilstein:
4162373
EC Number:
200-537-2
MDL number:
MFCD00011817
UNSPSC 코드:
12352211
PubChem Substance ID:
24277821
NACRES:
NA.25
분석:
≥98% (TLC)

Quality Level

100

분석

≥98% (TLC)

양식

powder

mp

171-173 °C (lit.)

solubility

H2O: 50 mg/mL (solutions undergo rapid, pH-dependent decomposition at pH > 6.)

저장 온도

−20°C

SMILES string

[Cl-].CC(C[N+](C)(C)C)OC(C)=O

InChI

1S/C8H18NO2.ClH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1

InChI key

JHPHVAVFUYTVCL-UHFFFAOYSA-M

유전자 정보

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

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애플리케이션

Acetyl-β-methylcholine (methacholine), an analog of acetylcholine, is use as a receptor agonist to study processes such as airway hyperresponsiveness associated with asthma.

생화학적/생리학적 작용

Metabolically stable analog of acetylcholine; muscarinic agonist. Its ability to constrict airway smooth muscle is used to assess bronchial reactivity in the laboratory and clinically.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
MKCQ3788
MKCQ3945
MKCP6579
MKCM4969
MKCN6991

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문서 라이브러리 방문

J G Martin et al.
Canadian journal of physiology and pharmacology, 70(4), 597-601 (1992-04-01)
Airway responsiveness to methacholine and other bronchoconstrictors is highly variable within and among species. The aim of the experiments in this report was to evaluate the importance of the quantity of airway smooth muscle as a determinant of intra- and
Bing Han et al.
PloS one, 6(2), e17236-e17236 (2011-03-02)
The great advances of nanomaterials have brought out broad important applications, but their possible nanotoxicity and risks have not been fully understood. It is confirmed that exposure of environmental particulate matter (PM), especially ultrafine PM, are responsible for many lung
Mina Youssef et al.
The Journal of pharmacology and experimental therapeutics, 373(3), 476-487 (2020-04-11)
Zona pellucida binding protein 2 (Zpbp2) and ORMDL sphingolipid biosynthesis regulator 3 (Ormdl3), mapped downstream of Zpbp2, were identified as two genes associated with airway hyper-responsiveness (AHR). Ormdl3 gene product has been shown to regulate the biosynthesis of ceramides. Allergic
Rifat A Chaudry et al.
Thorax, 69(6), 580-585 (2014-02-14)
Asthma and airway hyper-responsiveness are reportedly more common in children with sickle cell disease (SCD). To determine airway responsiveness, airway inflammation and clinical features of asthma in SCD. A prospective, single-centre study of 50 SCD children without overt pulmonary vascular
Mark J Hoegger et al.
Science (New York, N.Y.), 345(6198), 818-822 (2014-08-16)
Lung disease in people with cystic fibrosis (CF) is initiated by defective host defense that predisposes airways to bacterial infection. Advanced CF is characterized by a deficit in mucociliary transport (MCT), a process that traps and propels bacteria out of
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