402OA-05A

Human Chondrocytes - Osteoarthritis: HC-OA, adult

• 동의어(들): HC-OA cells
• UNSPSC 코드: 41106514
• NACRES: NA.81

속성

• 생물학적 소스: human articular cartilage (osteoarthritic)
• Quality Level: 100
• 포장: pkg of 500,000 cells
• 제조업체/상표: Cell Applications, Inc
• 성장 모드: Adherent
• 핵형: 2n = 46
• 형태학: chondrocyte
• 기술: cell culture | mammalian: suitable
• 관련 질환(들): arthritis
• 배송 상태: dry ice
• 저장 온도: −196°C

설명

일반 설명

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HC-OA Human Chondrocytes are derived from human articular cartilage of donors with osteoarthritis (OA). Osteoarthritis is an inflammatory disease characterized by increased degradation of cartilage tissue in the joint due to overproduction of enzymes degrading the extracellular matrix. Despite the initial proliferation and activation of chondrocytes, they are not able to efficiently repair the degrading cartilage. Instead, chondrocytes undergo terminal differentiation and eventually apoptose, leading to mineralization of cartilage in a process resembling bone formation during development. Thus, HC-OA provide a useful model to study changes in chondrocyte biology in response to abnormal environment of the OA joint.

Characterization: Positive for aggrecan after differentiation.

HC-OA have been used to demonstrate that THF-alpha activates transcription of ADAMTS-4, a metalloproteinase implicated in cartilage degradation in OA, via p38-MAPK-dependent mechanism (Xue, 2013).

세포주 기원

Cartilage

애플리케이션

model for studying chondrocyte biology in an osteoarthritis joint

성분

Basal Medium containing 10% FBS & 10% DMSO

제조 메모

• 1st passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO
• Can be cultured at least 10 doublings

계대배양 정규 작업

Please refer to the HC-OA Culture Protocol.

면책조항

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable