추천 제품
생물학적 소스
mouse
Quality Level
100
500
결합
unconjugated
항체 형태
culture supernatant
항체 생산 유형
primary antibodies
클론
MRQ-8, monoclonal
설명
For In Vitro Diagnostic Use in Select Regions (See Chart)
양식
buffered aqueous solution
종 반응성
human
포장
vial of 0.1 mL concentrate (358M-14)
vial of 0.5 mL concentrate (358M-15)
bottle of 1.0 mL predilute (358M-17)
vial of 1.0 mL concentrate (358M-16)
bottle of 7.0 mL predilute (358M-18)
제조업체/상표
Cell Marque®
기술
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
동형
IgG1κ
제어
B-cell chronic lymphocytic leukemia (B-CLL), plasma cell myeloma, tonsil
배송 상태
wet ice
저장 온도
2-8°C
시각화
cytoplasmic, nuclear
유전자 정보
human ... PWWP3A(84939)
일반 설명
MUM1 (multiple myeloma oncogene-1)/IRF4 (interferon regulatory factor 4) is a 50 kDa protein encoded by MUM1 gene, and a member of the interferon regulatory factor family of transcription factors. MUM1/IRF4 is expressed in the nuclei of plasma cells and a small percentage of germinal center (GC) B-cells located in the “light zone”. This antibody stains MUM1 protein, which is expressed in a subset of B-cells in the light zone of the germinal center, plasma cells, activated T-cells, and a wide spectrum of related hematolymphoid neoplasms derived from these cells. Therefore, this antibody is useful for the subclassiffication of lymphoid malignancies and an excellent marker for Reed-Sternberg cells of classic Hodgkin disease in combination with anti-CD30.
품질
 IVD |  IVD |  IVD |  RUO |
결합
MUM1 Positive Control Slides, Product No. 358S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
물리적 형태
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
제조 메모
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
기타 정보
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
법적 정보
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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시험 성적서(COA)
Lot/Batch Number
G Gaidano et al.
Leukemia, 14(4), 563-566 (2000-04-14)
In recent times, the field of B cell lymphoma histogenesis has progressed rapidly due to the increasing availability of histogenetic markers. Genotypic markers of B cell histogenesis are represented by mutations of IgV and BCL-6 genes, which are somatically acquired
Y Natkunam et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 14(7), 686-694 (2001-07-17)
The gene encoding MUM1 was characterized as a possible translocation partner in chromosomal abnormalities involving a significant number of multiple myelomas. The overexpression of the MUM1 protein as a result of translocation t(6;14) (p25;q32) identified MUM1 as a putative regulatory
B Falini et al.
Blood, 95(6), 2084-2092 (2000-03-09)
A new monoclonal antibody (MUM1p) was used to study the cell/tissue expression of human MUM1/IRF4 protein, the product of the homologous gene involved in the myeloma-associated t(6;14) (p25;q32). MUM1 was expressed in the nuclei and cytoplasm of plasma cells and
Antonino Carbone et al.
British journal of haematology, 117(2), 366-372 (2002-04-26)
Biological and clinical studies have shown that Hodgkin's disease (HD) can be divided into two major categories, termed nodular lymphocyte predominance HD (NLP HD) and classic HD (CHD). Within CHD four subtypes have been distinguished: nodular sclerosis, mixed cellularity, lymphocyte
Mathewos Tessema et al.
PloS one, 7(4), e34850-e34850 (2012-04-13)
Aberrant cytosine methylation affects regulation of hundreds of genes during cancer development. In this study, a novel aberrantly hypermethylated CpG island in cancer was discovered within the TOX2 promoter. TOX2 was unmethylated in normal cells but 28% lung (n =
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