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Merck
모든 사진(2)

Key Documents

354-05A

Sigma-Aldrich

Human Aortic Smooth Muscle Cells: HAOSMC, adult

동의어(들):

HAOSMC cells

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About This Item

UNSPSC 코드:
41106514
NACRES:
NA.81

생물학적 소스

human aorta (normal, tunica intima and tunica media, fibrous plaque-free)

Quality Level

포장

pkg of 500,000 cells

제조업체/상표

Cell Applications, Inc

성장 모드

Adherent

핵형

2n = 46

형태학

smooth muscle

기술

cell culture | mammalian: suitable

관련 질환(들)

cardiovascular diseases

배송 상태

dry ice

저장 온도

−196°C

일반 설명

Lot specific orders are not able to be placed through the web. Contact your local sales rep for more details.

Human Aortic Smooth Muscle Cells (HAOSMC) provide an excellent model system to study all aspects of cardiovascular function and disease, especially those related to mechanisms of hyperplasia and hypertrophy of intimal smooth muscle cells leading to vascular occlusion in atherosclerosis and stent restenosis.

HAOSMC have been utilized in dozens of research studies, for example, to:elucidate cytokines and growth factors signaling pathways implicated in the molecular regulation of smooth muscle cell proliferation, migration, and overall vascular function (Liu, 2009; Tan, 2009; Seymour, 2010; Chen, 2011; Hirase, 2013; Stein, 2013):
  • Understand hyperglycemia-related risk factors for atherosclerosis in diabetes patients (Maier, 2010), as well as effects of ethanol on vascular calcification (Oros, 2012)
  • Investigate extracellular elastic matrix deposition and its role in cardiovascular health, repair of damaged vasculature and successful tissue engineering (Gacchina, 2010, 2011; Venkataraman, 2012; Phillippi, 2013)
  • Study mechanisms and effects of mechanoregulation on proliferation and function of smooth muscle cells (Jiang, 2009; Venkataraman, 2013, 2014), and develop advanced stent technology, including novel surface materials, and drug and gene delivery systems to prevent restenosis and other occlusive vasculopathies (Brito, 2010; Deshpande, 2013; Kakade, 2013; Lamichhane, 2013)

Characterization: Positive for smooth muscle cell specific alpha-actin expression.

세포주 기원

Aorta

애플리케이션

aortic wall contraction, role of smc under normal conditions, blood pressure, distribution of oxygenated blood through systemic circulation

제조 메모

  • Can be cultured at least 16 doublings

계대배양 정규 작업

Please refer to the HAOSMC Culture Protocol.

면책조항

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서

Introduction of the modulation in expression profile for some genes and proteins when comparing 2D versus 3D cell culture conditions.

프로토콜

Technical information for working with human aortic smooth muscle cells including thawing, subculturing and cryopreservation.

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