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Merck
모든 사진(1)

주요 문서

113R-2

Sigma-Aldrich

CD13 (EP117) Rabbit Monoclonal Primary Antibody

동의어(들):

Aminopeptidase-N

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About This Item

UNSPSC 코드:
12352203

생물학적 소스

rabbit

Quality Level

100
500

결합

unconjugated

항체 형태

culture supernatant

항체 생산 유형

primary antibodies

클론

EP117, monoclonal

설명

For In Vitro Diagnostic Use in Select Regions (See Chart)

양식

buffered aqueous solution

종 반응성

human

포장

vial of 0.1 mL concentrate (113R-24)
vial of 0.1 mL concentrate Research Use Only (113R-24-RUO)
vial of 0.5 mL concentrate (113R-25)
vial of 1.0 mL concentrate (113R-26)
vial of 1.0 mL concentrate Research Use Only (113R-26-RUO)
vial of 1.0 mL pre-dilute Research Use Only (113R-27-RUO)
vial of 1.0 mL pre-dilute ready-to-use (113R-27)
vial of 7.0 mL pre-dilute ready-to-use (113R-28)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (113R-28-RUO)

제조업체/상표

Cell Marque

농도

0.1-5 μg/mL (predilute)
2.5-125 μg/mL (concentrate)

기술

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

동형

IgG

제어

liver

배송 상태

wet ice

저장 온도

2-8°C

시각화

cytoplasmic, membranous

유전자 정보

human ... ANPEP(290)

일반 설명

CD13 (aminopeptidase-N) is a transmembrane protease present in many tissues and cell types (e.g., endothelial and epithelial cells, fibroblasts, and leukocytes). CD13 is expressed in various solid and hematological malignancies in humans and is useful in identifying acute myeloid leukemia when used in a panel including antibodies against CD13(+), CD34(+), CD117(+), CD16(-), and CD33(+). This protein is also expressed in myeloid sarcoma and anti-CD13 is useful in its identification using a panel.

In addition, it has been reported that CD13 is expressed in both normal and neoplastic liver tissue, where it exhibits a canalicular distribution pattern similar to that seen for polyclonal CEA and CD10. Thus, anti-CD13 can be useful as an additional marker in differentiating between HCC and non-hepatocellular neoplasms.

품질

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

결합

CD13 Positive Control Slides, Product No. 113S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

물리적 형태

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

제조 메모

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기타 정보

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

법적 정보

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells.
Piedfer M, et al.
Faseb Journal, 25, 2831-2842 (2011)
Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma.
Rocken C, et al.
Journal of Clinical Pathology, 58, 1069-1075 (2005)
Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.
Bauvois B, et al.
Medicinal Research Reviews, 26, 88-130 (2006)
Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients.
Pileri SA, et al.
Leukemia, 21, 340-350 (2007)
Acute promyelocytic leukemia: four distinct patterns by flow cytometry immunophenotyping.
Gorczyca, W.
Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists, 1, 8-17 (2012)

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