SMB01318

3-Hydroxydesloratadine

• 동의어(들): 3-Hydroxy Desloratadine, Desloratadine 3-Hydroxy Impurity
• 실험식(Hill 표기법): C₁₉H₁₉ClN₂O
• CAS Number: 119410-08-1
• Molecular Weight: 326.82
• MDL number: MFCD00878381
• NACRES: NA.77

속성

• 설명: Modulation and Signaling
• Quality Level: 100
• 분석: ≥90%
• 형태: solid
• 기술: HPLC: suitable
• 색상: pale yellow to off-white
• 저장 온도: −20°C
• InChI: 1S/C19H19ClN2O/c20-15-3-4-17-13(9-15)1-2-14-10-16(23)11-22-19(14)18(17)12-5-7-21-8-6-12/h3-4,9-11,21,23H,1-2,5-8H2
• InChI key: NDFMTPISBHBIKE-UHFFFAOYSA-N

설명

일반 설명

3-hydroxy Desloratadine is a major metabolite of desloratadine and loratadine, which are non-sedating tricyclic antagonists of the histamine H1 receptor and antihistamine drugs used to manage allergic rhinitis and chronic idiopathic urticaria.

애플리케이션

3-Hydroxy Desloratadine finds application in metabolomics and drug discovery research

생화학적/생리학적 작용

3-hydroxydesloratadine formation involves the oxidation of desloratadine by cytochrome P450 (CYP2C8) and subsequent glucuronidation by UDP-glucuronosyltransferase UGT2B10 in cryopreserved human hepatocytes. This pathway leads to the production of 3-hydroxydesloratadine, a major active human metabolite.

특징 및 장점

• High quality compound suitable for multiple research applications
• Compatible with a wide variety of chromatographic and spectrometry techniques

기타 정보

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This product is intended for research purposes only, and it is not meant for human consumption.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable