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Merck
모든 사진(5)

Key Documents

S3674

Sigma-Aldrich

Succinic acid

greener alternative

BioXtra, BioRenewable, ≥99.0%

동의어(들):

Butanedioic acid

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About This Item

Linear Formula:
HOOCCH2CH2COOH
CAS Number:
Molecular Weight:
118.09
Beilstein:
1754069
EC Number:
MDL number:
UNSPSC 코드:
12352106
PubChem Substance ID:
NACRES:
NA.25

Quality Level

제품 라인

BioXtra

분석

≥99.0%

환경친화적 대안 제품 특성

Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

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불순물

≤0.01% Insoluble matter

무기 잔류물

≤0.02%

bp

235 °C (lit.)

mp

184-186 °C (lit.)

solubility

H2O: 0.5 M, clear, colorless

음이온 미량물

chloride (Cl-): ≤0.001%
sulfate (SO42-): ≤0.003%

양이온 미량물

Al: ≤0.0005%
Ca: ≤0.001%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

환경친화적 대안 카테고리

SMILES string

OC(=O)CCC(O)=O

InChI

1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

InChI key

KDYFGRWQOYBRFD-UHFFFAOYSA-N

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일반 설명

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애플리케이션

Succinic acid has been used:
  • in succinate dehydrogenase mitochondrial assay.
  • as an internal standard in mass spectroscopy.
  • as succinate dehydrogenase substrate in oxygraph analysis to measure respiration rates.

생화학적/생리학적 작용

Succinic acid is a byproduct of anaerobic fermentation in microbes. It is a dicarboxylic acid and an intermediate in Kreb′s cycle. Polymorphism in succinate dehydrogenase leads to succinate accumulation. High levels of succinate impairs 2-oxoglutarate epigenetic signalling. Succinate levels may modulate tumor progression. Succinate inhibits histone demethylation and may contribute to epigenetic changes. Succinate is crucial for interleukin-1 β (IL-1β) synthesis during inflammation and immune signalling.

픽토그램

Corrosion

신호어

Danger

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Oncometabolites: Unconventional triggers of oncogenic signalling cascades
Sciacovelli M and Frezza C
Free Radical Biology & Medicine, 100(9), 175-181 (2016)
Screening For Isolation of Succinic Acid Producing Microbes
Hema N and Sreenath KP
Biosciences, Biotechnology Research Asia, 15(2), 327-333 (2018)
Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue
Whitaker-Menezes D, et al.
Cell Cycle, 10(23), 4047-4064 (2011)
Cardiomyocyte differentiation: Experience and observations from 2 laboratories
Patten VA, et al.
SA heart journal, 14(2), 96-107 (2017)
Succinate: a new epigenetic hacker
Yang M and Pollard PJ
Cancer Cell, 23(6), 709-711 (2013)

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