85886

Streptomycin solution

~1 mg/mL in 1 mM EDTA, analytical standard

• 실험식(Hill 표기법): C₂₁H₃₉N₇O₁₂ · 1.5H₂SO₄
• CAS Number: 3810-74-0
• Molecular Weight: 728.69
• MDL number: MFCD00037023
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329769423
• NACRES: NA.24

속성

• Grade: analytical standard
• Quality Level: 100
• 형태: liquid
• 농도: ~1 mg/mL in 1 mM EDTA
• 기술: HPLC: suitable; gas chromatography (GC): suitable
• 색상: colorless
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• 응용 분야: pharmaceutical (small molecule)
• 형식: single component solution
• 동작 모드: protein synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N
• InChI: 1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1
• InChI key: QTENRWWVYAAPBI-YZTFXSNBSA-N

설명

일반 설명

Chemical structure: aminoglycoside

애플리케이션

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Streptomycin solution has been used as a standard in the determination of streptomycin, present in honey using high performance liquid chromatography(HPLC).

생화학적/생리학적 작용

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial Spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

포장

10ml

제조 메모

This product contains 1 mg/mL Streptomycin in 1 mM EDTA and should be stored at 2-8°C.

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves